补骨脂炮制历史沿革和机制研究进展及质量标志物(Q-Marker)预测  

Research progress on processing historical evolution and mechanism of PsoraleaFructus and its quality marker predictive analysis

作　　者：王静宜 吕明月 殷佳[3] 刘慧 刘凡敏 王丽媛 傅春升[4] WANG Jing-yi;LYU Ming-yue;YIN Jia;LIU Hui;LIU Fan-min;WANG Li-yuan;FU Chun-sheng(College of Pharmacy,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Department of Pharmacy,Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250014,China;Department of Thyroid Breast Surgery,Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250014,China;Science and Technology Division,Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250014,China)

机构地区：[1]山东中医药大学药学院,山东济南250355 [2]山东中医药大学附属医院药学部,山东济南250014 [3]山东中医药大学附属医院甲状腺乳腺外科,山东济南250014 [4]山东中医药大学附属医院科技处,山东济南250014

出　　处：《中草药》2023年第17期5759-5772,共14页Chinese Traditional and Herbal Drugs

基　　金：山东中医药科技发展计划项目(2019-0079)。

摘　　要：补骨脂Psoralea Fructus具有温肾壮阳、健脾等功效,但因辛热而燥,长用有伤阴之嫌,炮制可缓和偏燥之性,在我国传统中医药历史上应用广泛。通过查阅相关医学典籍及文献,对补骨脂的炮制方法历史沿革及现代炮制机制的研究进展进行总结。从化学成分可测性、成分与传统功效相关性、药动学及体内过程等对补骨脂的质量标志物(quality marker,Q-Marker)进行预测分析,初步确定补骨脂素、异补骨脂素、补骨脂二氢黄酮、补骨脂异黄酮、新补骨脂异黄酮、补骨脂酚等为其可能的Q-Marker,为补骨脂的炮制工艺传承、质量标准制定以及临床应用提供参考。Buguzhi(Psoralea Fructus)has the effect of warming the kidneys,assisting the yang,and strengthening the spleen,but because it is pungent-hot and dry,its prolonged use is suspected of harming yin.It can be tempered by processing and is therefore widely used in traditional Chinese medicine.The historical evolution of processing methods and the research progress of the modern processing mechanism of Psoralea Fructus were summarized by consulting the related medical classics and literature.The quality marker(Q-Marker)of Psoralea Fructus was predicted in terms of measurable chemical components,the correlation between composition and traditional efficacy,pharmacokinetics,and metabolic processes.Psoralen,isopsoralen,bavachin,corylin,neobavaisoflavone,and bakuchiol are preliminarily identified as possible Q-Markers.This study can provide a reference for the inheritance of the concoction process,quality standard development,and clinical application of Psoralea Fructus.

关 键 词：补骨脂 炮制 质量标志物 补骨脂素 异补骨脂素 补骨脂二氢黄酮 补骨脂异黄酮 补骨脂酚 

分 类 号：R285[医药卫生—中药学]