龙血竭及其主要活性成分对脑缺血的药理作用与机制研究进展  

Research progress of pharmacological effects and mechanism of Resina Draconis and its active constituents on cerebral ischemia

作　　者：陈品秋 班玮康 王文艳[2] 路娟[1] 陈曦[1] 杨志宏[1] CHEN Pin-qiu;BAN Wei-kang;WANG Wen-yan;LU Juan;CHEN Xi;YANG Zhi-hong(Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing100193,China;Key Laboratory of Molecular Pharmacology and Drug Evaluation,Ministry of Education,School of Pharmacy,Yantai University,Yantai 264005,China)

机构地区：[1]中国医学科学院北京协和医学院药用植物研究所,北京100193 [2]烟台大学药学院,分子药理和药物评价教育部重点实验室,山东烟台264005

出　　处：《中草药》2023年第18期6172-6184,共13页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(81973744);中国医学科学院医学与健康科技创新工程项目(N2022-I2M-2-001,2022-I2M-1-018);北京市自然科学基金资助项目(7173267)。

摘　　要：龙血竭Resina Draconis具有活血化瘀、消炎镇痛、生肌敛疮之功效,作为我国传统中药材及民族特色药材,常被称为“国产血竭”。现代研究表明龙血竭具有保护心脑血管系统、神经系统及抗肿瘤、促进组织愈合等药理作用,化学成分包括酚类、萜类、甾醇类等,活性成分以酚类为主,如紫檀茋、龙血素A、龙血素B、白藜芦醇等。大量研究已证实龙血竭能有效干预脑、心、肾等重要组织脏器的缺血再灌注损伤,对临床应用具有重要意义。通过梳理近十年国内外相关研究,总结了龙血竭及其主要酚类活性成分在抗氧化应激、抗炎、神经保护、保护血脑屏障、抗血栓等方面的药理作用及可能的作用机制,以期为该药在脑缺血防治领域的深入研发提供参考借鉴,助力其临床合理优效应用。As a traditional Chinese medicine with ethnic characteristics,Resina Draconis has the functions of activating blood circulation and removing blood stasis,reducing inflammation and analgesia,promoting muscle and healing sores,also known as“domestic Draconis Sanguis”with a long history of usage.Modern research has shown that Resina Draconis has pharmacological effects in protecting the cardiovascular and nervous systems,anti-tumor activity,and promoting tissue healing.The active ingredients of Resina Draconis are mainly phenols,terpenoids and steroids,such as pterostilbene,loureirin A,loureirin B and resveratrol.A large number of studies have provided substantial evidence that Resina Draconis can effectively intervene in the ischemia-reperfusion injury of brain,heart,kidneys and other vital organs,which is of great significance for clinical application.In the review,the pharmacological effects and possible mechanisms of Resina Draconis in anti-oxidative stress,anti-inflammatory properties,neuroprotection,protection of the blood-brain barrier,and anti-thrombotic were systematically summarized based on both domestic and foreign studies in recent 10 years.It is expected to provide a reference for the future development of Resina Draconis in the field of cerebral ischemia prevention and treatment to facilitate its clinical application.

关 键 词：龙血竭 脑缺血 缺血再灌注损伤 紫檀茋 龙血素A 龙血素B 白藜芦醇 

分 类 号：R28[医药卫生—中药学] R285[医药卫生—中医学]