基于阿霉素纳米共递体系的抗肿瘤联合治疗  

Combination Antitumor Therapy based on Codelivery Nanosystems of Doxorubicin

作　　者：包予晗 郭子峰 李金涛 张明祖 何金林 倪沛红 Yuhan Bao;Zifeng Guo;Jintao Li;Mingzu Zhang;Jinlin He;Peihong Ni(College of Chemistry,Chemical Engineering and Materials Science,State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials,Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application,Suzhou Key Laboratory of Macromolecular Design and Precision Synthesis,Soochow University,Suzhou 215123,China)

机构地区：[1]苏州大学材料与化学化工学部新型功能高分子材料国家地方联合工程实验室江苏省先进功能高分子材料设计及应用重点实验室苏州市大分子设计与精密合成重点实验室,苏州215123

出　　处：《化学进展》2023年第8期1123-1135,共13页Progress in Chemistry

基　　金：江苏省高等学校自然科学研究重大项目(No.20KJA 150009);江苏省高等学校大学生创新创业训练计划项目(No.202110285025Z)

摘　　要：肿瘤是当前全球范围内的主要致死病因,而化疗仍是抗肿瘤治疗的重要手段之一。阿霉素(DOX)是一种临床上广泛使用的蒽环类广谱抗肿瘤药物,但是它的治疗效果受到其严重副作用的限制,包括累积性心脏毒性和剂量限制性骨髓抑制。研究人员长期致力于寻找降低DOX毒副作用的方法,而依托于纳米共递体系的抗肿瘤联合治疗策略获得广泛关注。它们能够实现药物在病灶区域的靶向富集和定点释放,通过药物联用降低DOX对正常细胞组织的不良反应,并在一定程度上逆转肿瘤细胞的多药耐药性。本综述将聚焦于近年来基于DOX的纳米共递体系用于抗肿瘤联合治疗策略的构筑,重点介绍DOX联合其他化疗药物、基因药物、气体分子或天然药物进行抗肿瘤治疗的研究进展,并对其面临的挑战和发展趋势进行展望。Cancer has been one of the most common causes of death worldwide,while chemotherapy is still the major tool for antitumor treatment.As a broad-spectrum anthracycline-type antitumor drug,doxorubicin(DOX)has been widely used in numerous types of tumors in clinical practices.Nevertheless,its serious side effects,including cumulative cardiotoxicity and dose-limiting myelosuppression,presents great significant challenges to the clinical application.Researchers have long been committed to finding routes to reduce the toxic side effects of DOX,whereas the strategies of combination antitumor therapies based on codelivery nanosystems have received wide attentions.They can realize the targeted enrichment and ondemand release of drugs in the lesion area,reducing the adverse reaction of DOX to normal tissues through drug combination and reversing the multi-drug resistance(MDR)of tumor cells to a certain extent.In this review,we focus on the recent progress on the DOX-based combination antitumor therapies together with other chemotherapeutic agents(camptothecin,paclitaxel,cisplatin),genetic drugs(pDNA,siRNA,miRNA),gas molecules(NO,O_(2),CO,H_(2)S,SO_(2))or natural medicines(dexrazoxane,berberine,flavonoids).Besides,the challenges and future trends of DOX-based combination therapies are also prospected.

关 键 词：阿霉素 抗肿瘤治疗 联合治疗 纳米共递体系 肿瘤微环境 

分 类 号：O631[理学—高分子化学] TB381[理学—化学]