1,6-己二醇选择氧化内酯化制备ε-己内酯  

Selective Oxidative Lactonization of 1,6-Hexanediol intoε-Caprolactone

作　　者：申小雨 杜中田[1] 郭百睿 郭忠旭 梁长海[1,2] Xiaoyu Shen;Zhongtian Du;Bairui Guo;Zhongxu Guo;Changhai Liang(School of Chemical Engineering,Dalian University of Technology,Panjin 124221,China;State Key Laboratory of Fine Chemicals,Dalian University of Technology,Dalian 116023,China)

机构地区：[1]大连理工大学化工学院,盘锦124221 [2]大连理工大学精细化工国家重点实验室,大连116023

出　　处：《化学进展》2023年第8期1191-1198,共8页Progress in Chemistry

基　　金：国家自然科学基金项目(No.22172010);中央高校基本科研业务费(DUT2021TD103)资助。

摘　　要：ε-己内酯是合成聚己内酯(PCL)等聚合物的关键单体,相关高分子材料具有良好的生物降解性和兼容性,在生物医药、环保材料等领域具有重要应用。ε-己内酯的绿色廉价制备是制约这类材料广泛使用的重要因素,其中1,6-己二醇选择氧化内酯化制备ε-己内酯有待进一步发展。本文分析对比了环己酮Baeyer-Villiger氧化法和1,6-己二醇氧化内酯化法制备ε-己内酯的优缺点,按照反应体系中是否加入电子受体(氧化剂)分类介绍了国内外1,6-己二醇选择氧化内酯化制备ε-己内酯相关的研究进展,并对相应反应体系、所用催化剂的优缺点进行了评述,最后对该转化过程的发展趋势进行了展望。ε-Caprolactone is a key monomer for the synthesis of poly(ε-caprolactone)(PCL)with good biocompatibility and biodegradability,and relevant polymer materials could be applied in pharmaceutical,medicinal,and packaging applications.Green and economic synthesis ofε-caprolactone is vital to popularize such eco-friendly polymers,and selective oxidative lactonization of 1,6-hexanediol intoε-caprolactone remains to be developed.In this review,different routes for the synthesis ofε-caprolactone such as Baeyer-Villiger oxidation of cyclohexanone and oxidative lactonization of 1,6-hexanediol are comparatively analyzed.According to whether electron acceptors(oxidants)are added to the reaction systems,the related advances of oxidative lactonization of 1,6-hexanediol are summarized,and the advantages and disadvantages of the corresponding reaction systems and catalysts are reviewed.The development trend of oxidative lactonization of 1,6-hexanediol intoε-caprolactone is also proposed.

关 键 词：聚己内酯 Ε-己内酯 1 6-己二醇 催化氧化 催化脱氢 分子氧 

分 类 号：O623.5[理学—有机化学] O623.624[理学—化学]