ω-3长链多不饱和脂肪酸治疗视网膜疾病的分子机制及研究现状  

Macular Mechanism and Research Status of ω-3 Long-Chain Polyunsaturated Fatty Acids in the Treatment of Retinal Diseases

作　　者：王捷 韩国鸽[1] 韩泉洪[1] Jie Wang;Guoge Han;Quanhong Han(Tianjin Eye Hospital,Clinical College of Ophthalmology,Tianjin Medical University,Tianjin 300020,China)

机构地区：[1]天津市眼科医院天津医科大学眼科临床学院,天津300020

出　　处：《中华眼视光学与视觉科学杂志》2023年第9期715-720,共6页Chinese Journal Of Optometry Ophthalmology And Visual Science

基　　金：国家自然科学基金青年项目(81700849);天津市自然科学基金青年项目(18JCQNJC10600)。

摘　　要：炎症、氧化应激、病理性新生血管生成以及视网膜神经细胞的凋亡在视网膜疾病的发生发展中扮演着重要角色,是年龄相关性黄斑变性、视网膜色素变性、糖尿病视网膜病变以及早产儿视网膜病变的共同致病机制。ω-3长链多不饱和脂肪酸(ω-3 LC-PUFAs)作为视网膜的重要组成成分,其抗炎、抗氧化应激、抑制新生血管生成、促进神经细胞存活的作用已经得到证实。ω-3 LC-PUFAs及其衍生物在预防和治疗视网膜疾病时涉及多个过程,深入挖掘其与病理机制间的关系,或许可为治疗提供潜在靶点。现对ω-3 LC-PUFAs及其衍生物对视网膜疾病的治疗机制及现阶段的研究进展做一综述,以期为具有类似发病机制的视网膜疾病提供新的治疗方向。Inflammation,oxidative stress,pathological neovascularization,and apoptosis of retinal nerve cells play an important role in the development of retinal diseases.They are common pathogenic mechanisms in diseases such as age-related macular degeneration(AMD),retinitis pigmentosa(RP),diabetic retinopathy(DR),and retinopathy of prematurity(ROP).ω-3 long-chain polyunsaturated fatty acids(ω-3 LC-PUFAs),as important components of the retina,have been shown to have anti-inflammatory and anti-oxidative stress effects,inhibit neovascularization,and promote neuronal cell survival.ω-3 LC-PUFAs and their derivatives are involved in many processes in the prevention and treatment of retinal diseases,and deeper investigation of their relationship with pathological mechanisms may provide potential targets for treatment.The purpose of this article is to review the therapeutic mechanisms ofω-3 LC-PUFAs and their derivatives in retinal diseases and the current research progress,with the aim of providing new therapeutic directions for retinal diseases with similar pathogenesis.

关 键 词：长链多不饱和脂肪酸 年龄相关性黄斑变性 糖尿病性视网膜病变 视网膜色素变性 早产儿视网膜病变 病理性新生血管生成 

分 类 号：R587.2[医药卫生—内分泌] R774.1[医药卫生—内科学]