基于孟德尔随机化方法探索可干预风险因素与肺结核之间的因果关系  

Exploring the causal relationship between intervenable risk factors and tuberculosis based on Mendelian randomization methods

作　　者：胡鹏远 彭孝旺 买吾拉江·依马木 王艳杰[1] 樊晓蕾 向阳[1] HU Peng-yuan;PENG Xiao-wang;Maiwuajiang Yimamu;WANG Yan-jie;FAN Xiao-ei;XIANG Yang(School of Public Health,Xinjiang Medical University,Urumqi,Xinjiang 830017,China;不详)

机构地区：[1]新疆医科大学公共卫生学院,新疆乌鲁木齐830017 [2]新疆喀什地区卫生健康委员会 [3]新疆喀什地区疾病预防控制中心

出　　处：《现代预防医学》2023年第18期3414-3419,共6页Modern Preventive Medicine

基　　金：新疆维吾尔自治区自然科学基金(2022D01C203)。

摘　　要：目的使用孟德尔随机化方法探索可干预的风险因素与肺结核之间的因果关系.方法利用GWAS数据库中的大样本汇总数据,以单核苷酸多态性作为工具变量,在两样本孟德尔随机化模型中,运用5种孟德尔随机化方法评估16个可干预风险因素与肺结核发生之间因果关联.统计结果报告为优势比(Odds ratio,OR)及其95%置信区间(Confidence intervals,CI).使用留一法、水平多效性检验进行敏感性分析.结果目前吸烟情况(OR=39.24,95%CI:4.12~373.63)会增加结核病发生的风险,受教育时间(OR=0.60,95%CI:0.37~0.96)及转铁蛋白饱和度(OR=0.69,95%CI:0.50~0.96)与TB发生风险降低之间也存在因果关系.留一法显示结果稳健,MR-Egger截距值未显示水平多效性的存在.结论基因预测目前吸烟情况、受教育时间以及转铁蛋白饱和度与肺结核的患病风险存在因果关系.Objective To explore the causal relationship between intervenable risk factors and tuberculosis using Mendelian randomization methods.Methods Five Mendelian randomization methods were used to assess the causal associations between 16 intervenable risk factors and tuberculosis incidence using large samples of pooled data from the GWAS database,with single nucleotide polymorphisms as instrumental variables,in a two-sample Mendelian randomization model.Statistical results were reported as Odds ratios(OR)and their 95%confidence intervals(CI).Sensitivity analyses were performed using the leave-one-out method and the horizontal multiple validity test.Results Current smoking status(OR=39.24,95%CI:4.12~373.63)increased the risk of tuberculosis occurrence,and there was also a causal association between time in education(OR=0.60,95%Cl:0.37~0.96),transferrin saturation(0R=0.69,95%CI:0.50~0.96)and a reduced risk of tuberculosis occurrence.The leave-one-out method showed robust results,and MR-Egger intercept values did not indicate the presence of horizontal pleiotropy.Conclusion Genes predict a causal relationship between current smoking status,duration of education,and transferrin saturation and the risk of tuberculosis.

关 键 词：孟德尔随机化 肺结核 可干预风险因素 因果关系 

分 类 号：R521[医药卫生—内科学]