基于阴阳毒理论探讨系统性红斑狼疮的预后及治疗  

Prognosis and Treatment of Systemic Lupus Erythematosus Based on Yin-Yang Toxin Theory

作　　者：单雪燕 刘瑞华[2] 郭子琳 唐晓颇[2] SHAN Xueyan;LIU Ruihua;GUO Zilin;TANG Xiaopo(Beijing University of Chinese Medicine,Beijing 100029;Guang'anmen Hospital,China Academy of Chinese Medical Sciences)

机构地区：[1]北京中医药大学,北京市100029 [2]中国中医科学院广安门医院

出　　处：《中医杂志》2023年第18期1926-1929,共4页Journal of Traditional Chinese Medicine

基　　金：国家中医药管理局国家中医临床研究基地建设项目(国中药科技函[2018]131号)。

摘　　要：基于《金匮要略》对阴阳毒的论述,探究系统性红斑狼疮与阴阳毒的关系。发现二者症状相似,预后不良因素存在潜在联系,且系统性红斑狼疮尽早治疗可改善预后的思想与中医学阴阳毒应早期诊治的观点不谋而合。故而提出以阴阳为总括、毒邪为致病关键阐述系统性红斑狼疮病机,以阴阳毒理论为指导,围绕病理要素“毒、热、瘀”论治系统性红斑狼疮,且治疗中应兼顾肾元。据此,提出以升麻鳖甲汤为基础方根据疾病不同证型与分期灵活治疗,为系统性红斑狼疮的临床诊疗提供参考。This paper explored the relationship between systemic lupus erythematosus(SLE)and yin-yang toxins based on the discussion of yin-yang toxin in Synopsis of the Golden Chamber(《金匮要略》),and found that the two are similar in symptoms,and there is a potential relationship between adverse prognosis factors;and the idea that early treatment of SLE can improve prognosis is in accordance with the opinion in traditional Chinese medicine claiming that yin-yang toxin should be diagnosed and treated as soon as possible.Therefore,it is proposed to take yin-yang as general and toxin pathogen as key to explain the pathogenesis,use yin-yang toxin theory for guidance,discuss on the treatment of SLE around the pathological elements including“toxin,heat,stasis”,and take into account of the kidney essence.Accordingly,Shengma Biejia Decoction(升麻鳖甲汤)is recommended as the basic formula with modifications in accordance with different syndromes in staged treatment,providing reference for the clinical diagnosis and treatment of SLE.

关 键 词：系统性红斑狼疮 阴阳毒 《金匮要略》 预后 升麻鳖甲汤 

分 类 号：R259[医药卫生—中西医结合]