七氟烷吸入麻醉与丙泊酚静脉麻醉在小儿手术中的应用效果比较  

Comparison of the Application Effects of Sevoflurane Inhalation Anesthesia and Propofol Intravenous Anesthesia in Pediatric Surgery

作　　者：王伟鑫[1] 刘雪霞[1] 申玲玲[1] 王媛[1] 焦丽 WANG Weixin;LIU Xuexia;SHEN Lingling;WANG Yuan;JIAO Li(Surgical Department of the Seventh People’s Hospital of Zhengzhou City,Zhengzhou 450000,Henan,China)

机构地区：[1]郑州市第七人民医院手术部,河南郑州450000

出　　处：《中国药物滥用防治杂志》2023年第9期1521-1525,共5页Chinese Journal of Drug Abuse Prevention and Treatment

基　　金：2019年度河南省医学科技攻关计划联合共建项目(编号:LHGJ20191376)。

摘　　要：目的:对比七氟烷吸入麻醉与丙泊酚静脉麻醉在小儿手术中的应用价值。方法:选取2020年8月—2022年8月我院收治的100例小儿手术患者作为研究对象,根据麻醉方式分为对照组和观察组,每组50例。对照组应用丙泊酚静脉麻醉,观察组应用七氟烷吸入麻醉,比较两组麻醉效果、血流动力学、应激反应、镇静镇痛效果及躁动发生率。结果:观察组麻醉起效时间、睁眼时间、清醒时间和定向力恢复时间短于对照组,麻醉诱导期和苏醒期躁动发生率高于对照组(P<0.05);观察组切皮时、切皮5min收缩压、舒张压、呼吸频率高于对照组,心率低于对照组(P<0.05);观察组切皮时肾素、肾上腺素和去甲肾上腺素低于对照组(P<0.05);观察组入恢复室即刻和入室5 min的PAED和MOPS评分低于对照组(P<0.05)。结论:与丙泊酚静脉麻醉比较,于小儿手术中运用七氟烷吸入麻醉可维持血流动力学稳定性,减少应激反应,利于患儿恢复,但躁动风险高。Objective:To compare the application value of sevoflurane inhalation anesthesia and propofol intravenous anesthesia in pediatric surgery.Methods:A total of 100 pediatric surgery patients admitted to our hospital from August 2020 to August 2022 were selected as the research objects.According to the anesthesia method,they were divided into a control group and an observation group,with 50 patients in each group.The control group was given propofol intravenous anesthesia,and the observation group was given sevoflurane inhalation anesthesia.The anesthetic effect,hemodynamics,stress response,sedative and analgesic effect and the incidence of agitation were compared between the two groups.Results:The onset time of anesthesia,eye opening time,awake time and orientation recovery time in the observation group were shorter than those in the control group,and the incidence of agitation during anesthesia induction and recovery was higher than that in the control group(P<0.05).The systolic blood pressure,diastolic blood pressure and respiratory rate of the observation group were higher than those of the control group at the time of skin incision and 5 min after skin incision,and the heart rate was lower than that of the control group(P<0.05).The levels of renin,epinephrine and norepinephrine in the observation group were lower than those in the control group(P<0.05).The PAED and MOPS scores of the observation group were lower than those of the control group immediately and 5 minutes after entering the recovery room(P<0.05).Conclusion:Compared with propofol intravenous anesthesia,sevoflurane inhalation anesthesia in pediatric surgery can maintain hemodynamic stability,reduce stress response,and facilitate the recovery of children,but has a high risk of agitation.

关 键 词：七氟烷吸入麻醉 丙泊酚静脉麻醉 小儿手术 血流动力学 应激指标 躁动 

分 类 号：R726.1[医药卫生—儿科]