单采血小板献血者新型冠状病毒IgM和IgG抗体水平监测结果分析及对血液安全的影响  

Analysis of monitoring results of novel coronavirus IgM and IgG antibody levels in apheresis platelets donors and impact on blood safety

作　　者：张翙 王心维 何汝汝 韦振兴 梁进恒 庞栋 陈利民[2] ZHANG Hui;WANG Xinwei;HE Ruru;WEI Zhenxing;LIANG Jinheng;PANG Dong;CHEN Limin(Nanning Blood Center,Nanning 530007,China;Institute of Blood Transfusion,Chinese Academy of Medical Sciences&Peking Union Medical College)

机构地区：[1]南宁中心血站,广西南宁530007 [2]中国医学科学院北京协和医学院输血研究所

出　　处：《中国输血杂志》2023年第9期770-774,共5页Chinese Journal of Blood Transfusion

基　　金：南宁市科技局(2022年):中国(广西)-东盟血液安全国际科技合作示范基地建设。

摘　　要：目的监测无偿献血者感染SARS-CoV-2康复后IgM和IgG抗体阳性率及S/CO值的动态变化情况,为保障血液安全提供理论依据及数据支持。方法以符合纳入标准的单采血小板献血者54人为研究对象,采用全自动化学发光法,连续监测T1—T7共7个时间点(跨度14~15周)359份血液标本(血浆)SARS-CoV-2 IgM和IgG抗体。结果1)纳入符合标准共计54人,提供359份血液标本(血浆)用于检测,有效检测结果349份。2)时间段内IgM检测呈阳性11人,阳性率20.37%;IgM抗体S/CO值T1—T3逐步升高,T4—T7逐步下降。3)时间段内IgG检测呈阳性54人,阳性率100%;IgG抗体S/CO值随时间变化逐步降低。4)在T1—T7时间段内,SARS-CoV-2 IgG抗体S/CO值在性别(男/女)及年龄段(18~39岁/40~60岁)均无差异(P>0.05)。结论单采血小板献血者感染SARS-CoV-2康复后,2~14周SARS-CoV-2 IgG抗体阳性率为100%,IgG S/CO值随时间推移逐步下降,献血者SARS-CoV-2血清学特异性IgG、IgM抗体更长时间的动态变化规律值得进一步追踪研究。Objective To monitor the positive rates of IgM and IgG antibodies and the changes in S/CO values over time in voluntary blood donors infected with SARS⁃CoV⁃2 after recovery,in order to provide theoretical basis and data support for ensuring clinical blood safety.Methods A total of 54 platelet donors who met the inclusion criteria were selected for this study,and 359 blood samples(plasma)from T,to T,(at 7 time points,spanning 14 to 15 weeks)were continuously monitored for SARS-CoV-2 IgM and IgG antibodies using fully automated chemiluminescence method.Results Among 359 blood samples(plasma)from 54 donors,349 were with valid test results.Eleven donors were tested positive for IgM,with a positive rate of 20.37%,and IgM antibody S/CO value gradually increased during T,-T,,but gradually decreased during T4-T,.Fifty-four donors were tested positive for IgG,with the positive rate of 100%,and the S/CO value of IgG antibody gradually decreased over time.During the period of T,-T,,there was no significant difference in SARS-CoV-2 IgG antibody S/CO value between gender(male/female)or age group(18-39 years old/40-60 years old).Conclusion The positive rate of SARS-CoV-2 IgG antibody in platelet donors after recovery from SARS-CoV-2 infection was 100%during 2-14 weeks,and the IgG S/CO value gradually decreases over time.The long-term dynamic changes of SARS-CoV-2 serologically specific IgG and IgM antibodies in blood donors are worthy of further study.

关 键 词：单采血小板 新型冠状病毒 IGM抗体 IgG抗体 血液安全 

分 类 号：R457[医药卫生—治疗学]