新冠病毒感染患者恢复期血浆抗体效价的相关因素分析  

Analysis of related factors of plasma antibody titer in convalescent patients with COVID⁃19

作　　者：胡欣 徐华[1] 冯娜[1] 丁瑾 李凤琴[1] HU Xin;XU Hua;FENG Na;DING Jin;LI Fengqin(Shaanxi Blood Center,Xi′an 710000,China)

机构地区：[1]陕西省血液中心,陕西西安710000

出　　处：《中国输血杂志》2023年第9期774-776,共3页Chinese Journal of Blood Transfusion

摘　　要：目的研究新冠病毒感染康复者恢复期血浆IgG、IgM、中和抗体效价与性别、年龄、采集间隔等因素的关系,从而指导新冠病毒感染康复者血浆采集。方法采集新冠恢复期患者血浆,测定抗体效价,采用SPSS统计学分析软件,分析各组数据差异性及相关性。结果不同性别与3种抗体效价(男性IgG、IgM、中和抗体效价中位数分别为484.24 AU/mL、2.13 AU/mL、1124.74 AU/mL;女性IgG、IgM、中和抗体效价中位数分别为516.04 AU/mL、1.73 AU/mL、1143.99 AU/mL)组间比较无差异(P>0.05),年龄与IgG、中和抗体有弱的正相关,Spearman相关系数为0.188(P<0.05);30名重复捐献者,首次捐献IgG、IgM、中和抗体效价中位数分别为522.3 AU/mL、2.64 AU/mL、1174.6 AU/mL,再次捐献3种抗体效价中位数为332.08 AU/mL、0.63 AU/mL、708.96AU/mL,前后浓度水平比较有差异(P<0.05)。结论不同年龄、性别的新冠病毒感染康复者恢复期血浆IgG、IgM、中和抗体效价水平无差异,其效价水平均可达到临床治疗指南要求。重复捐献者抗体水平虽有所下降,但仍具有临床价值。Objective To study the relationship between the plasma IgG,IgM,neutralizing antibody titer and sex,age,collection interval in convalescent patients with COVID⁃19,so as to guide the plasma collection of convalescent patients with COV⁃ID-19.Methods COVID-19 convalescent plasma was collected to determine the antibody titer,and the difference and correlation of data in each group were analyzed by SPSS statistical analysis software.Results The median titers(AU/mL)of IgG,IgM and neutralizing antibodies in males and females were 484.24 vs 516.04,2.13 us 1.73,and 1124.74 vs 1143.99,respectively,and there was no significant difference(P>0.05).Age had weak positive correlation with IgG and neutralizing antibody,and the Spearman correlation coefficient was 0.188(P<0.05).The median titers(AU/mL)of IgG,IgM and neutralizing antibody at first donation of 30 repeated donors were 522.3,2.64 and 1174.6,respectively,but at second donation were 332.08,0.63 and 708.96,showing significant difference(P<0.05).Conclusion There was no significant difference in the plasma IgG,IgM and neutralizing antibody titers in convalescent COVID-19 patients of different ages and genders,and the titers met the requirements of clinical treatment guidelines.Although the plasma antibody level of repeated donors has decreased,it still has clinical value.

关 键 词：新冠病毒感染恢复期血浆 IgG、IgM抗体 中和抗体 

分 类 号：R457.1[医药卫生—治疗学]