多次单采血小板对献血者血小板指标及聚集率的影响分析  

Effect of multiple apheresis platelet donation on platelet indexes and aggregation rate in platelet donors

作　　者：梁菊玲 罗益红[1] 卓创近[1] 陈燕佳 庞晓丹[1] 伍伟健[1] LIANG Jul-ing;LUO Yihong;ZHUO Chuangjin;CHEN Yanjia;PANG Xiaodan;WU Weijian(Foshan Central Blood Station,Foshan 528000,China)

机构地区：[1]佛山市中心血站,广东佛山528000

出　　处：《中国输血杂志》2023年第9期807-810,共4页Chinese Journal of Blood Transfusion

摘　　要：目的探讨多次单采血小板是否影响献血者血小板指标及聚集功能,分析献血者血小板指标之间以及与血小板聚集率的关系。方法随机选取佛山市中心血站2021年9月—2022年10月单采献血者83名,根据献血次数将其分为对照组和研究组,其中首次血小板捐献者或距上次血小板捐献间隔时间>1年者9例为对照组,非首次血小板捐献者或距上次血小板捐献间隔时间≤1年者74例为研究组,研究组分为4个亚组:2~5次组、6~10次组、11~15次组、16次组,检测并分析各组单采前血小板计数(Plt)、血小板分布宽度(PDW)、平均血小板体积(MPV)、大型血小板比率(P-LCR)以及血小板最大聚集率(MAR)。结果研究组各亚组Plt、MPV、PDW、P-LCR、MAR同对照组比较无统计学差异(P>0.05),研究组各亚组Plt、MPV、PDW、P-LCR、MAR组间比较无统计学差异(P>0.05)。献血者Plt与MAR呈正相关关系(P<0.05),相关系数为0.445;MPV、PDW、P-LCR与MAR呈负相关关系(P<0.05),相关系数分别为-0.282、-0.233、-0.217。Plt与MPV、PDW、P-LCR呈负相关关系(P<0.05),相关系数分别为-0.399、-0.307、-0.339;MPV、PDW、P-LCR三者互为正相关关系,其中MPV与PDW相关系数为0.792,MPV与P-LCR相关系数为0.863,PDW与P-LCR相关系数为0.817。结论多次捐献血小板对献血者Plt、PDW、MPV、P-LCR及MAR无明显影响。单采献血者血小板指标中Plt对MAR影响最明显。Objective To investigate the effect of multiple apheresis platelet donation on platelet indexes and aggrega⁃tion function in platelet donors,and to analyze the relationship between platelet indexes and their relationship with platelet aggregation rate.Methods A total of 83 platelet donors were randomly selected from Foshan Central Blood Station from Sep⁃tember 2021 to October 2022,and were divided into control group(n=9,first⁃time platelet donors or donors with the time in⁃terval from the last platelet donation>1 year)and study group(n=74,repeat platelet donors or donors with the time interval from the last platelet donation≤1 year)according to the times of blood donation.The study group was divided into 4 sub⁃groups:2-5 times group,6-10 times group,11-15 times group and 16 times group.The platelet count(Plt),platelet distri⁃bution width(PDW),mean platelet volume(MPV),large platelet ratio(P⁃LCR),and maximum platelet aggregation rate(MAR)before donation in each group were detected and analyzed.Results There were no significant differences in Plt,MPV,PDW,P⁃LCR and MAR between the subgroups and the control group(P>0.05),and there were no significant differ⁃ences in Plt,MPV,PDW,P⁃LCR and MAR between each subgroup(P>0.05).There was a positive correlation between Plt and MAR in blood donors(P<0.05),and the correlation coefficient was 0.445.MPV,PDW and P⁃LCR were negatively cor⁃related with MAR(P<0.05),and the correlation coefficients were-0.282,-0.233 and-0.217,respectively.Plt was nega⁃tively correlated with MPV,PDW and P⁃LCR(P<0.05),and the correlation coefficients were-0.399,-0.307 and-0.339,respectively.MPV,PDW and P⁃LCR are positively correlated with each other.The correlation coefficient between MPV and PDW was 0.792,that between MPV and P⁃LCR was 0.863,and tthat between PDW and P⁃LCR was 0.817.Con⁃clusion There was no significant effect of multiple platelet donations on Plt,PDW,MPV,P⁃LCR and MAR in blood do⁃nors.Plt has the most significant impact on MAR among platelet i

关 键 词：单采血小板 献血次数 血小板聚集率 

分 类 号：R331.143[医药卫生—人体生理学] R193.3[医药卫生—基础医学]