利拉鲁肽联合低碳水化合物饮食在超重/肥胖型2型糖尿病中的应用  

Application of Liraglutide combined with Low-carbohydrate Diet in Overweight and Obese Type 2 Diabetes

作　　者：许春芳 王素芳[1] 张捷报 方朝晖[2] 程梅[2] XU Chun-fang;WANG Su-fang;ZHANG Jie-bao(Public Health Preventive Medicine,Anhui Medical University,Hefei 230032,China;Department of Endocrinology,The First Affiliated Hospital of Anhui University of Chinese Medicine,Hefei 230038,China)

机构地区：[1]安徽医科大学公共卫生预防医学,安徽合肥230032 [2]安徽中医药大学第一附属医院内分泌科,安徽合肥230038

出　　处：《吉林医学》2023年第10期2831-2834,共4页Jilin Medical Journal

基　　金：国家自然基金面上项目[项目编号:81573944];安徽省高校协同创新项目[项目编号:GXXT-2020-025];安徽中医药大学第一附属医院临床科研项目[项目编号:2020yfyzc68]。

摘　　要：目的:探讨利拉鲁肽联合低碳水化合物饮食在超重/肥胖型2型糖尿病中的应用价值。方法:选取60例超重/肥胖型2型糖尿病患者为研究对象,随机分对照组与观察组各30例。对照组予以二甲双胍联合糖尿病饮食治疗,观察组予以利拉鲁肽联合低碳水化合物饮食治疗,连续治疗3个月。3个月后比较两组腰围、臀围、体重指数(BMI)、空腹血糖(FPG)、餐后2 h血糖(2 hPG)、糖化血红蛋白(HbA1c)、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C),观察治疗期间有无不良反应。结果:治疗3个月后,观察组腰围、臀围、BMI、FPG、2 hPG、HbA1c、TG、TC、LDL-c均低于对照组,HDL-C高于对照组,差异有统计学意义(P<0.05)。两组用药期间不良反应比较差异无统计学意义(P>0.05)。结论:利拉鲁肽联合低碳水化合物饮食在超重/肥胖型2型糖尿病降低血糖及糖化血红蛋白,降低患者腰围、臀围、BMI,改善血脂指标,未增加不良反应,安全性好。Objective To explore the application value of liraglutide combined with low-carbohydrate diet in overweight and obese type 2 diabetes.Method 60 patients with overweight/obese type 2 diabetes mellitus were selected and randomly divided into control group and observation group,with 30 cases each group.The control group was treated with metformin combined with diabetic diet,the observation group was treated with liraglutide combined with low-carbohydrate diet,and the two groups were treated continuously for 3 months.After 3 months,the waist circumference,hip circumference,body mass index(BMI),fasting blood glucose(FPG),postprandial 2 h blood glucose(2 hPG),glycosylated hemoglobin(HbA1c),triacylglycerol(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),and high-density lipoprotein cholesterol(HDL-C)were compared between the two groups,and whether there were any adverse reactions during treatment.Results After 3 months of treatment,the waist circumference,hip circumference,BMI,FPG,2 hPG,HbA1c,TG,TC,LDL-C in the observation group were lower than those in the control group,HDL-C was higher than that of the control group,the difference was statistically significant(P<0.05).There was no significant difference in adverse reactions during the administration of the two groups(P>0.05).Conclusion Liraglutide combined with low-carbohydrate diet in overweight/obese type 2 diabetes mellitus can lower blood sugar and glycated hemoglobin,reduce patients'waist circumference,hip circumference,BMI,and improve blood lipid index,no adverse reactions are increased during medication,and the safety is high.

关 键 词：利拉鲁肽 低碳水化合物饮食 超重/肥胖 2型糖尿病 糖脂代谢指标 体重指数 

分 类 号：R587.1[医药卫生—内分泌]