联合抗炎治疗伴腺样体肥大儿童OSAHS的效果评价  

The clinical effect of combined anti-inflammatory treatment on obstructive sleep apnea hypopnea syndrome(OSAHS)in children with adenoid hypertroph

作　　者：黄娟 万方锐 吴冬 HUANG Juan;WAN Fangrui;WU Dong(Department of Pediatric,the Third Hospital of Nanchang,Nanchang 330009,Jiangxi,China)

机构地区：[1]南昌市第三医院儿科,江西南昌330009

出　　处：《中国现代医生》2023年第27期23-26,共4页China Modern Doctor

基　　金：江西省卫生健康委科技计划项目(SKJP220217836)。

摘　　要：目的评估鼻用激素与孟鲁司特钠联合抗炎治疗伴腺样体肥大的轻中度阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome,OSAHS)儿童的疗效及安全性。方法选取2019年8月至2021年6月南昌市第三医院收治的76例合并腺样体肥大的轻中度OSAHS儿童为研究对象,随机分为观察组和对照组。对照组给予常规治疗,观察组给予糠酸莫米松鼻喷雾剂与孟鲁司特钠联合抗炎治疗,比较两组患儿治疗前后各项睡眠和呼吸参数变化及药物不良反应,分析其临床疗效及安全性。结果观察组治疗后阻塞性呼吸暂停低通气指数(obstructive apnea hypopnea index,OAHI)、觉醒指数(awaking index,AI)降低,睡眠效率(sleep efficiency,SE)和最低血氧饱和度(lowest oxygen saturation,LSpO2)升高,差异有统计学意义(P<0.05)。对照组治疗后SE有所提高,差异有统计学意义(P<0.05),治疗前后其他睡眠和呼吸参数差异无统计学意义(P>0.05)。观察组治疗后OAHI、AI低于对照组,LSpO2高于对照组,差异有统计学意义(P<0.05)。治疗过程中,两组患儿均未出现反复鼻黏膜出血、头痛及噩梦、抑郁、攻击行为等精神症状。结论糠酸莫米松鼻喷雾剂与孟鲁司特钠联合抗炎治疗对伴有腺样体肥大的轻中度儿童OSAHS是一种安全、有效的治疗方法。Objective To evaluate the efficacy and safety of combined anti-infla mmatory treatment of nasal hormone and montelukast sodium on obstructive sleep apnea hypopnea syndrome(OSAHS)in children with adenoid hypertrophy.Methods A total of 76 cases with mild-to-moderate OSAHS and adenoid hypertrophy admittde to the Third Hospital of Nanchang from August 2019 to June 2021 were selectde as the search subjects and divided into trial group and control group according to random method.The trial group were treated with mometasone furoate aqueous nasal spray and montelukast sodium,control group were treated by conventional treatment.By comparing the relevant indicators before and after treatment to evaluate drug efficacy and safety.Results In trail group,the obstructive apnea hypopnea index(OAHI)and awaking index(AI)were lower,while the sleep efficiency(SE)and the lowest oxygen saturation(LSpO2)were higher,the differences were statistically significant(P<0.05).In control group,SE was higher,the differences were statistically significant(P<0.05),but there were no significant differences in the other respiratory parameters(P>0.05).Afert treatment,the OAHI and AI in trial group were lower than those in control group,while the LSpO2 was higher than that in control group,the differences were statistically significant(P<0.05).During the treatment,neither of the two groups developed the mental symptoms such as recurrent nasal mucosal,headache,nightmare,depression and aggressive behaviour.Conclusion Mometasone furoate aqueous nasal spray and montelukast sodium are safe,effective methods for treatment of OSAHS in children with adenoid hypertrophy.

关 键 词：糠酸莫米松鼻喷雾剂 孟鲁司特钠 腺样体肥大 阻塞性睡眠呼吸暂停低通气综合征 儿童 

分 类 号：R729[医药卫生—儿科]