HIV/AIDS女性宫颈病变及组织表达p16和Ki67相关情况研究  

A study on cervical lesions and tissue expression of p16 and Ki67 in women with HIV/AIDS

作　　者：李英伟[1,3] 蒙华 牟敏红 陈人[1] 陆梅燕 Li Yingwei;Meng Hua;Mu Minhong;Chen Ren;Lu Meiyan(Department of Obstetrics and Gynecology,The Fourth People's Hospital of Nanning,Nanning 530013,China;Department of Pathology,The Fourth People's Hospital of Nanning,Nanning 530013,China;Department of Obstetrics and Gynecology,Jiangbin Hospital of Guangxi,Nanning 530021,China;Department of Quality Control,Wuming Hospital Affiliated to Guangxi Medical University,Nanning 530100,China)

机构地区：[1]南宁市第四人民医院妇产科,广西南宁530013 [2]南宁市第四人民医院病理科,广西南宁530013 [3]广西壮族自治区江滨医院妇产科,广西南宁530021 [4]广西医科大学附属武鸣医院质控科,广西南宁530100

出　　处：《实用妇科内分泌电子杂志》2023年第17期8-12,共5页Electronic Journal of Practical Gynecological Endocrinology

基　　金：HIV/AIDS女性高级别宫颈上皮内瘤变和宫颈癌发病年龄段及病变组织p16和Ki67表达的研究(编号Z20200124)。

摘　　要：目的 探讨HIV/AIDS女性宫颈病变及组织表达p16和Ki67相关情况。方法 选取南宁市第四人民医院收治的57例HIV阳性CINⅡ~Ⅲ级女性患者为CIN组,32例HIV阳性宫颈分化鳞状上皮细胞癌ⅠB期女性患者为宫颈癌组。比较两组的一般资料、不同年龄患病人数、p16及Ki67表达情况。结果 CIN组40~49岁人群最为常见(35.09%),宫颈癌组50~59岁人群最为常见(31.25%);CIN组p16表达阳性率、Ki67表达阳性率、p16与Ki67共同表达阳性率分别为82.46%、87.72%、82.46%,低于宫颈癌组的93.75%、93.75%、93.75%(P<0.05)。结论 HIV/AIDS女性人群中,一定年龄范围内,宫颈病变严重程度与年龄呈正相关,病毒感染时间越长,宫颈病变程度越重;p16及Ki67表达与HIV/AIDS女性宫颈组织病变严重程度密切相关。Objective To explore the cervical lesions and tissue expression of p16 and Ki67 in women with HIV/AIDS.Methods 57 HIV positive CIN Ⅱ~Ⅲ female patients admitted to the Fourth People's Hospital of Nanning City were selected as CIN group,and 32 HIV positive cervical differentiated squamous cell carcinoma I B female patients were selected as cervical cancer group.Compare the general information,number of patients at different ages,and expression of p16 and Ki67 between the two groups.Results The CIN group aged 40-49 was the most common(35.09%),while the cervical cancer group aged 50-59 was the most common(31.25%);The positive rates of p16 expression,Ki67 expression,and co expression of p16 and Ki67 in the CIN group were 82.46%,87.72%,and 82.46%,respectively,which were lower than the 93.75%,93.75%,and 93.75%of the cervical cancer group(P<0.05).Conclusion In the HIV/AIDS female population,within a certain age range,the severity of cervical lesions is positively correlated with age.The longer the duration of virus infection,the more severe the degree of cervical lesions;The expression of p16 and Ki67 is closely related to the severity of cervical tissue lesions in women with HIV/AIDS.

关 键 词：人类免疫缺陷病毒 宫颈上皮内瘤变 宫颈癌 

分 类 号：R512.91[医药卫生—内科学] R737.33[医药卫生—临床医学]