胃复春胶囊联合西药治疗脾虚型慢性萎缩性胃炎临床研究  

Clinical Study on Weifuchun Capsules Combined with Western Medicine for Chronic Atrophic Gastritis of Spleen Deficiency Type

作　　者：朱晟易[1] 姚林华[1] 危贵君[1] ZHU Shengyi;YAO Linhua;WEI Guijun(Department of Gastroenterology,The First People's Hospital of Huzhou,Huzhou Zhejiang 313000,China)

机构地区：[1]湖州市第一人民医院消化内科,浙江湖州313000

出　　处：《新中医》2023年第17期102-106,共5页New Chinese Medicine

基　　金：浙江省医学会临床医学科研项目(2021ZYC-A137)。

摘　　要：目的:观察胃复春胶囊联合西药治疗脾虚型慢性萎缩性胃炎(CAG)的临床疗效。方法:选取92例脾虚型CAG患者为研究对象,采用随机数字表法分为试验组和对照组各46例。对照组采用常规西药治疗,试验组在对照组基础上加用胃复春胶囊,均治疗12周。比较2组治疗前后中医证候积分、胃镜病理积分,胃液中游离酸、乳酸、总酸度及pH值,胃黏膜血流量情况。结果:治疗前,2组中医证候积分、胃镜病理积分比较,差异无统计学意义(P>0.05);治疗后,试验组中医证候积分、胃镜病理积分均降低(P<0.05),且试验组低于对照组(P<0.05)。治疗前,2组胃液中游离酸、乳酸、总酸比较,差异无统计学意义(P>0.05)。治疗后,2组游离酸、总酸含量均升高(P<0.05),乳酸含量均降低(P<0.05),且试验组胃液中总酸、游离酸含量高于对照组(P<0.05),乳酸含量低于对照组(P<0.05)。治疗前,2组胃液pH值分布比较,差异无统计学意义(P>0.05)。治疗后,2组pH值分布比较,差异有统计学意义(P<0.05)。治疗前,2组胃窦前壁、胃窦后壁、胃窦大弯、胃窦小弯胃黏膜血流量比较,差异无统计学意义(P>0.05);治疗后,2组上述胃黏膜血流量均增加(P<0.05),且试验组多于对照组(P<0.05)。结论:胃复春胶囊联合西药治疗脾虚型CAG,可改善患者临床症状和病理状态,调节胃液中游离酸、乳酸、总酸度含量及pH值,改善胃黏膜血流量,临床疗效优于单用西药治疗。Objective:To observe the clinical effect of Weifuchun Capsules combined with western medicine for chronic atrophic gastritis(CAG)of spleen deficiency type.Methods:A total of 92 cases of CAG patients of spleen deficiency type were selected as the study objects and divided into the trial group and the control group according to the random number table method,with 46 cases in each group.The control group was treated with conventional western medicine,and the trial group was additionally treated with Weifuchun Capsules based on the treatment of the control group.Both groups were treated for 12 weeks.Traditional Chinese medicine(TCM)syndrome scores,gastroscopy and pathological scores,free acid,lactic acid,total acidity and pH values in gastric juice,and gastric mucosal blood flow were compared before and after treatment between the two groups.Results:Before treatment,there was no significant difference being found in the comparison of TCM syndrome scores and gastroscopy and pathological scores between the two groups(P>0.05).After treatment,TCM syndrome scores and gastroscopy and pathological scores in the two groups were decreased when compared with those before treatment(P<0.05),and the scores in the trial group were lower than those in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparison of free acid,lactic acid and total acidity in gastric juice between the two groups(P>0.05).After treatment,the contents of free acid and total acidity in the two groups were increased(P<0.05),and the contents of lactic acid were decreased(P<0.05);the contents of free acid and total acidity in gastric juice in the trial group were higher than those in the control group(P<0.05),and the content of lactic acid in the trial group was lower than that in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparison of the distribution of pH values in gastric juice between the two groups(P>0.05).After treatment,the comparison of the distri

关 键 词：慢性萎缩性胃炎 胃复春胶囊 胃液 胃黏膜血流量 中医证候积分 胃镜病理积分 

分 类 号：R259[医药卫生—中西医结合] R573.3[医药卫生—中医内科学]