肾衰宁片联合百令胶囊治疗慢性肾功能衰竭血液透析临床研究  

Clinical Study on Shenshuaining Pills Combined with Bailing Capsules for Chronic Renal Failure Treated with Hemodialysis

作　　者：鹿鸣华 田其生[1] 孙艳梅[1] LU Minghua;TIAN Qisheng;SUN Yanmei(Department of Nephrology,Zhoukou Central Hospital,Zhoukou He'nan 466000,China)

机构地区：[1]周口市中心医院肾内科,河南周口466000

出　　处：《新中医》2023年第17期122-127,共6页New Chinese Medicine

摘　　要：目的:观察肾衰宁片联合百令胶囊治疗慢性肾功能衰竭(CRF)血液透析的临床疗效。方法:采用随机数字表法将106例CRF拟行血液透析患者分为对照组与观察组各53例。对照组给予常规治疗,观察组在对照组基础上给予肾衰宁片与百令胶囊联合治疗。比较2组治疗前后中医证候积分、氧化应激指标[超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、丙二醛(MDA)]、炎症指标[超敏C-反应蛋白(hs-CRP)、白细胞介素-6 (IL-6)、肿瘤坏死因子-α (TNF-α)]、肠黏膜屏障功能指标[D-乳酸(D-LA)、二胺氧化酶(DAO)、内毒素(LPS)]、肾功能指标[尿素氮(BUN)、肌酐(SCr)、内生肌酐清除率(CCr)]、营养状况指标[血红蛋白(Hb)、前白蛋白(PAB)、血白蛋白(ALB)],评估2组临床疗效及不良反应发生情况。结果:观察组治疗总有效率90.57%,高于对照组73.58%(P<0.05)。治疗后,2组MDA、hs-CRP、IL-6、TNF-α、D-LA、DAO、LPS、BUN、SCr水平及中医证候积分均较治疗前降低(P<0.05),SOD、GSH-Px、CCr、Hb、PAB、ALB水平均升高(P<0.05),且观察组治疗后炎症指标、MDA、D-LA、DAO、LPS、BUN、SCr水平及中医证候积分均低于对照组(P<0.05),营养状况指标及SOD、GSH-Px、CCr水平均高于对照组(P<0.05)。观察组不良反应发生率7.55%,低于对照组22.64%(P<0.05)。结论:肾衰宁片联合百令胶囊治疗CRF血液透析疗效确切,能够减轻患者氧化应激反应与微炎症状态,改善肾功能、营养状况及肠黏膜屏障功能,安全性较高。Objective:To observe the clinical effect of Shenshuaining Pills combined with Bailing Capsules for chronic renal failure(CRF)treated with hemodialysis.Methods:A total of 106 cases of CRF patients who were about to undergo hemodialysis were divided into the control group and the observation group according to the random number table method,with 53 cases in each group.The control group was given routine treatment,and the observation group was additionally treated with Shenshuaining Pills combined with Bailing Capsules based on the treatment of the control group.The following indicators were compared between the two groups,namely traditional Chinese medicine(TCM)syndrome scores,oxidative stress indicators[superoxide dismutase(SOD),glutathione peroxidase(GSH-Px),and malondialdehyde(MDA)],inflammatory indicators[high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6),and tumor necrosis factor-α(TNF-α)],intestinal mucosal barrier function indicators[D-lactic acid(D-LA),diamine oxidase(DAO),and lipopolysaccharides(LPS)],renal function indicators[blood urea nitrogen(BUN),serum creatintine(SCr),endogenous creatinine clearance rate(CCr)],and nutritional status indicators[hemoglobin(Hb),prealbumin(PAB),and blood albumin(ALB)].Clinical effects and the incidence of adverse reactions were evaluated in the two groups.Results:The total effective rate was 90.57%in the observation group,higher than that of 73.58%in the control group(P<0.05).After treatment,the levels of MDA,hs-CRP,IL-6,TNF-α,D-LA,DAO,LPS,BUN,and SCr,as well as the TCM syndrome scores in the two groups were decreased when compared with those before treatment(P<0.05),and the levels of SOD,GSH-Px,CCr,Hb,PAB,and ALB were increased(P<0.05);after treatment,the levels of inflammatory indicators,MDA,D-LA,DAO,LPS,BUN,and SCr,as well as TCM syndrome scores in the observation group were lower than those in the control group(P<0.05),and the levels of nutritional status indicators,SOD,GSH-Px,and CCr in the observation group were higher than those in the control grou

关 键 词：慢性肾功能衰竭 血液透析 肾衰宁片 百令胶囊 氧化应激 炎症因子 营养状况 肠黏膜屏障功能 

分 类 号：R692.5[医药卫生—泌尿科学]