早期干预治疗对早期筛查阳性子痫前期孕妇妊娠结局的影响  

Effect of Early Intervention on Pregnancy Outcome of Pregnant Women with Early Screening Positive Preeclampsia

作　　者：霍春霞 谢玲[1] 张爱萍 HUO Chun-xia;XIE Ling;ZHANG Ai-ping(The First Department of Obstetrics,Qinghai Red Cross Hospital,Xining 810000,Qinghai,China)

机构地区：[1]青海红十字医院产一科,青海西宁810000

出　　处：《医学信息》2023年第19期134-136,140,共4页Journal of Medical Information

基　　金：青海省科技计划项目(编号:2020-ZJ-783)。

摘　　要：目的分析早期干预治疗对早期筛查阳性子痫前期孕妇妊娠结局的影响。方法选取2021年1月-2022年12月我院收治的45例早期筛查阳性子痫前期孕妇为研究对象,采用随机数字表法分为观察组(n=23)和对照组(n=22)。对照组给予常规治疗,观察组在对照组基础上给予阿司匹林肠溶片进行早期干预治疗,比较两组临床治疗效果、血清可溶性fms样酪氨酸激酶-1(sFlt-1)、胎盘生长因子(PLGF)水平、孕妇不良妊娠结局发生率、并发症发生率、不良反应发生率。结果观察组治疗总有效率为95.65%,高于对照组的81.82%(P<0.05);观察组治疗后PLGF水平高于对照组,sFlt-1水平低于对照组(P<0.05);观察组孕妇并发症发生率为13.04%,低于对照组的45.45%(P<0.05);观察组胎儿不良妊娠结局发生率为8.70%,低于对照组的36.36%(P<0.05);观察组不良反应发生率与对照组比较,差异无统计学意义(P>0.05)。结论早期干预治疗可提升早期筛查阳性子痫前期孕妇的治疗疗效,降低孕妇并发症发生率,改善胎儿不良妊娠结局,提高PLGF水平,降低sFlt-1水平,且不会增加不良反应。Objective To analyze the effect of early intervention on pregnancy outcome of pregnant women with early screening positive preeclampsia.Methods A total of 45 pregnant women with early screening positive preeclampsia admitted to our hospital from January 2021 to December 2022 were selected as the research objects.They were divided into observation group(n=23)and control group(n=22)by random number table method.The control group was given routine treatment,and the observation group was given aspirin enteric-coated tablets for early intervention on the basis of the control group.The clinical efficacy,serum soluble fms-like tyrosine kinase-1(sFlt-1),placental growth factor(PLGF)levels,incidence of adverse pregnancy outcomes,incidence of complications,and incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 95.65%,which was higher than 81.82%in the control group(P<0.05).The PLGF level in the observation group was higher than that in the control group,and the sFlt-1 level was lower than that in the control group(P<0.05).After treatment,the incidence of complications in the observation group was 13.04%,which was lower than 45.45%in the control group(P<0.05).The incidence of fetal adverse pregnancy outcomes in the observation group was 8.70%,which was lower than 36.36%in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the observation group and the control group(P>0.05).Conclusion Early intervention treatment can improve the therapeutic effect for pregnant women with early screening positive preeclampsia,reduce the incidence of complications,improve fetal adverse pregnancy outcomes,increase PLGF level,reduce sFlt-1 level,and will not increase adverse reactions.

关 键 词：子痫前期 早期干预治疗 妊娠结局 

分 类 号：R714.244[医药卫生—妇产科学]