IgA、IgG、IgM及补体C3、C4对类风湿关节炎患者的诊断价值  

Diagnostic Value of IgA,IgG,IgM and Complement C3 and C4 in Patients With Rheumatoid Arthritis

作　　者：尚明全[1] 柏立欣[1] 左晓雪 李连友[1] SHANG Mingquan;BAI Lixin;ZUO Xiaoxue;LI Lianyou(Department of Laboratory,Chifeng Municipal Hospital,Chifeng Inner Mongolia 024000,China)

机构地区：[1]赤峰市医院检验科,内蒙古赤峰024000

出　　处：《中国卫生标准管理》2023年第18期118-121,共4页China Health Standard Management

摘　　要：目的分析免疫球蛋白组及补体3(complement 3,C3)、补体4(complement 4,C4)在类风湿关节炎(rheumatoid arthritis,RA)临床诊断中的应用价值。方法选择2020年3月—2022年10月赤峰市医院收治的88例初诊RA患者作为观察组,并选择同期健康人群64名作为对照组。其中RA患者依据疾病活动分数(disease activity score 28,DAS28)进行分级,高度活动组22例、中度活动组24例、低度活动组21例、缓解组21例。对每个纳入研究的RA患者及健康人群均行免疫球蛋白A(immunoglobulin A,IgA)、免疫球蛋白G(immunoglobulin G,IgG)、免疫球蛋白M(immunoglobulin M,IgM)及补体C3、C4检测。比较两组患者及不同分级RA患者间各指标的差异,并分析讨论。结果观察组患者IgA、IgG、IgM、C3、C4水平较对照组均明显升高(P<0.05)。观察组内不同活动度RA患者对比,活动度越高,对应患者IgA、IgG、IgM、C3、C4水平也明显偏高,而缓解组患者各指标水平最低(P<0.05)。结论RA患者血清免疫球蛋白及补体指标较正常人群会有所升高,且RA活动度越高,其对应指标升高程度也越明显。提示免疫球蛋白及补体可以作为RA患者早期诊断及检测的评价指标;同时,本文的研究结果也为类风湿关节炎后期诊断标准制定提供了借鉴。Objective To analyze the value of immunoglobulin group and complement 3(C3)and complement 4(C4)in the clinical diagnosis of rheumatoid arthritis(RA).Methods A total of 88 newly diagnosed RA patients admitted to Chifeng Municipal Hospital from March 2020 to October 2022 were selected as the observation group,and 64 healthy people in the same period were selected as the control group.Among them,RA patients were classified based on disease activity score 28(DAS28),with 22 cases in the high activity group,24 cases in the moderate activity group,21 cases in the low activity group,and 21 cases in the remission group.Immunoglobulin A(IgA),immunoglobulin G(IgG),immunoglobulin M(IgM),and complement C3,C4 were tested for each RA patient and healthy population included in the study.The differences in various indicators between the two groups of patients and RA patients of different grades were compared and analyzed for discussion.Results The levels of IgA,IgG,IgM,C3,and C4 in the observation group were significantly higher than those in the control group(P<0.05).Comparison of RA patients with different levels of activity within the observation group showed that the higher the activity,the higher the levels of IgA,IgG,IgM,C3,and C4 in the corresponding patients.However,the lowest levels of various indicators were observed in the remission groups(P<0.05).Conclusion The levels of immunoglobulin and complement in the serum of RA patients will increase compared to the normal population,and the higher the activity of RA,the more obvious the corresponding indicators will be.This suggests that immunoglobulin and complement can be used as evaluation indicators for early diagnosis and detection of RA patients.At the same time,the research results of this article also provide reference for the development of diagnostic standards for rheumatoid arthritis in the later stage.

关 键 词：免疫球蛋白 IGA IGG IGM 补体C3 补体C4 类风湿关节炎 临床诊断 

分 类 号：R593[医药卫生—内科学]