盐酸氨溴索联合地塞米松鼓室内注射治疗分泌性中耳炎的效果  

Effect of Ambroxol Hydrochloride Combined With Dexamethasone Intratympanic Injection in the Treatment of Secretory Otitis Media

作　　者：阮神炯 邱恩惠[1] 吴淮阳 RUAN Shenjiong;QIU Enhui;WU Huaiyang(Department of Otolaryngology,the Second Affiliated Hospital of Fujian Medical University,Quanzhou Fujian 362500,China)

机构地区：[1]福建医科大学附属第二医院耳鼻咽喉科,福建泉州362500

出　　处：《中国卫生标准管理》2023年第18期143-146,共4页China Health Standard Management

摘　　要：目的在分泌性中耳炎(secretoryotitismedia,SOM)患者的治疗中,将盐酸氨溴索与地塞米松联合注射于鼓室内,对其疗效展开探究。方法选取福建医科大学附属第二医院2020年3月—2023年1月收治的60例SOM患者,以随机方式分为对照组和观察组,每组30例。对照组单独施与地塞米松,观察组则联合盐酸氨溴索及地塞米松。比较两组的治疗效果、炎症因子、纯音测听气导、鼓室压以及生活质量。结果观察组总有效率为96.67%,高于对照组的73.33%(P<0.05);观察组治疗后白细胞介素-8(interleukin-8,IL-8)、白细胞介素-10(interleukin-10,IL-10)、白细胞介素-β(interleukin-β,IL-β)低于对照组,差异有统计学意义(P<0.05);观察组治疗后纯音测听气导低于对照组,鼓室压高于对照组,差异有统计学意义(P<0.05);观察组不同维度下生活质量评分均高于对照组,差异有统计学意义(P<0.05)。结论针对SOM患者而言,将盐酸氨溴索及地塞米松经鼓室注射进行治疗,该方式可有效缓解疾病所带来的相关症状,改善听力和生活质量,降低疾病所带来的负面影响,具有较为显著的临床应用价值。Objective In the treatment of secretory otitis media(SOM)patients,ambroxol hydrochloride and dexamethasone were injected into the tympanic cavity to explore its efficacy.Methods A total of 60 patients with SOM admitted to the Second Affiliated Hospital of Fujian Medical University from March 2020 to January 2023 were randomly divided into control group and observation group,with 30 cases in each group.The control group was given dexamethasone alone,and the observation group was given ambroxol hydrochloride combined with dexamethasone.The therapeutic effect,inflammatory factors,pure tone audiometry,air conductance,tympanic pressure and quality of life were compared between the two groups.Results The total effective rate of the observation group was 96.67%,higher than that of the control group(73.33%)(P<0.05).After treatment,interleukin-8(IL-8),interleukin-10(IL-10)and interleukin-β(interleukin-β)in observation group were lower than those in control group,and the difference was statistically significant(P<0.05).After treatment,the pure tone audiometry gas conductivity in the observation group was lower than that in the control group,and tympanic pressure was higher than that in the control group,the difference was statistically significant(P<0.05).The quality of life scores of the observation group were higher than those of the control group in different dimensions,and the difference was statistically significant(P<0.05).Conclusion For SOM patients,ambroxol hydrochloride and dexamethasone are injected through tympanic cavity for treatment,which can effectively alleviate the related symptoms caused by the disease,improve hearing and quality of life,and reduce the negative impact of the disease,and has significant clinical application value.

关 键 词：分泌性中耳炎 盐酸氨溴索 地塞米松 鼓室内注射 生活质量 改善作用 

分 类 号：R764[医药卫生—耳鼻咽喉科]