微重力场下对抗性训练对骨小梁和成骨细胞力学行为影响的模拟研究  

Simulation study on effect of antagonism training on mechanical behaviors of trabecular bone and osteoblasts in microgravity

作　　者：田从彪 刘海英[1,2] 赵超辉 张春秋[1,2] TIAN Cong-biao;LIU Hai-ying;ZHAO Chao-hui;ZHANG Chun-qiu(Tianjin Key Laboratory for Advanced Mechatronic System Design and Intelligent Control,Tianjin University of Technology,Tianjin 300384,China;National Demonstration Center for Experimental Mechanical and Electrical Engineering Education,Tianjin University of Technology,Tianjin 300384,China)

机构地区：[1]天津理工大学天津市先进机电系统设计与智能控制重点实验室,天津300384 [2]天津理工大学机电工程国家级实验教学示范中心,天津300384

出　　处：《医疗卫生装备》2023年第8期23-28,共6页Chinese Medical Equipment Journal

基　　金：国家自然科学基金面上项目(12072235)。

摘　　要：目的:研究微重力场下宇航员对抗性训练对骨小梁和成骨细胞的力学行为影响,从一定程度上揭示微重力场下对抗性训练防治废用性骨质疏松的生物力学机理。方法:建立包含骨小梁、成骨细胞和骨髓的松质骨有限元模型,将骨小梁和成骨细胞定义为各向同性线弹性材料,模拟研究地球重力场(1×g)和微重力场(0×g)下,人体静止(应变幅值为0με)及不同强度的运动状态时(应变幅值分别为100、700、2000和3000με)骨小梁、成骨细胞的力学微环境(液体流速、液体压力、von Mises应力、应变)的变化规律。结果:地球重力场和微重力场下,人体运动时成骨细胞表面的液体流速均高于静止状态,且地球重力场下成骨细胞表面的液体流速高于微重力场。微重力场下,相比静止状态,运动可明显提高骨小梁、成骨细胞的液体压力,且相同运动条件下骨小梁、成骨细胞的液体压力无较大差异;不同强度的对抗性训练均可对骨小梁、成骨细胞产生一定的应力刺激,而骨小梁的von Mises应力与对抗性训练强度呈正相关;成骨细胞的应变值明显高于骨小梁,而且骨小梁、成骨细胞应变均与加载位移呈正相关。结论:微重力场下,宇航员进行对抗性训练可明显改善骨组织和成骨细胞的力学微环境,有助于维持骨密度,从而减轻废用性骨质疏松症。Objective To study the effect of antagonism training on mechanical behaviors of trabecular bone and osteoblasts in the microgravity field to reveal to some extent its biomechanical mechanism of antagonism training for preventing and controlling disuse osteoporosis.Methods A finite element model for cancellous bone containing osteoblasts and bone marrow was established.Trabecular bone and osteoblasts were defined as isotropic linear elastic materials,and simulation study in the earth's gravity field(1×g)and the microgravity field(0×g)was carried out on the change rules of the mechanical microenvironment involving in liquid flow rate,liquid pressure,von Mises stress and strain for trabecular bone and osteoblasts in case the human body was at rest with the strain amplitude being 0μεand the motion state with different intensities(strain amplitude of 100,700,2000,and 3000με,respectively).Results On the surface of osteoblasts the average flow velocity at rest state was higher than that at motion state in the earth's gravity field and microgravity field,and the velocity in the earth's gravity was higher than that in the microgravity field.In the microgravity field,the liquid pressures of trabecular bone and osteoblasts at motion state were higher than those at rest state,and there were no significant differences between the liquid pressures of trabecular bone and osteoblasts under the same motion conditions;antagonism training with different intensities resulted in stress stimulation to trabecular bone and osteoblasts,and the von Mises stress of trabecular bone was positively correlated with antagonism training strength;the strain value of osteoblasts was significantly higher than that of trabecular bone,and both the strains of trabecular bone and osteoblasts correlated positively with the loading displacements.Conclusion In the microgravity field antagonism training for astronauts can obviously improve the mechanical microenvironment of trabecular bone and osteoblasts,which helps maintain bone density and thus al

关 键 词：微重力场 骨小梁 成骨细胞 力学行为影响 废用性骨质疏松 

分 类 号：R318[医药卫生—生物医学工程]