不同血管活性药对重度子痫前期患者腰硬联合麻醉剖宫产母儿健康的影响观察  

Observation on the Effects of Different Vasoactive Drugs on the Health of Mothers and Infants Undergoing Cesarean Section under combined Spinal Epidural Anesthesia in Severe Preeclampsia Patients

作　　者：李瑞芝 LI Ruizhi(Anqiu Maternal and Child Health Hospital,Anqiu 262100,China)

机构地区：[1]安丘市妇幼保健院,山东安丘262100

出　　处：《中国医药指南》2023年第28期39-42,共4页Guide of China Medicine

摘　　要：目的 探讨不同血管活性药对重度子痫前期患者腰硬联合麻醉剖宫产母儿健康的影响。方法 本研究选取了安丘市妇幼保健院在2017年12月至2018年12月进行择期联合阻滞麻醉下剖宫产手术的75例重度子痫前期产妇作为研究对象,采用随机数字表法将其分为3组,每组25例。预注不同血管活性药物是治疗重度子痫前期的有效方法之一。这些药物包括氨甲环酸、硝普钠、拉贝洛尔。所有患者将接受随访,以记录产妇在不同时间点的血压和心率水平变化,同时评估新生儿脐动脉和脐静脉的血气指标水平。研究旨在比较3种不同药物对母婴的影响。结果 对3组产妇在不同时间点的血压水平进行比较,发现在第1、10、12和15分钟时,3组之间的差异均无统计学意义(P>0.05)。在第3、5和7分钟时,C组的血压水平明显低于A、B两组,且差异有统计学意义(P<0.05)。这些数据表明,不同的药物使用可能会对产妇的血压水平产生不同的影响,C组使用的药物可能具有一定的降压效果。第1分钟时,3组之间的差异无统计学意义(P>0.05)。在第3、5、7、10、12、15分钟时,C组的心率水平均高于A、B两组(P<0.05)。此外,B组在5 min后的心率水平也比A组高,这种差异有统计学意义(P<0.05)。这些数据表明,3组使用的药物可能会对产妇的心率水平产生不同的影响,C组使用的药物可能会使产妇的心率升高,而B组的心率水平也可能高于A组。3组新生儿脐动脉、脐静脉中乳酸、PCO_(2)、PO_(2)、BE以及pH水平比较,差异无统计学意义(P>0.05)。在随访过程中发现,A、B组各有1例患者出现了恶心和呕吐症状(5.00%),而C组有14例患者出现了这种症状(70.00%)。因此,与C组相比,A、B组的恶心呕吐发生率较低,差异有统计学意义的。这些数据表明,在使用不同药物时,产妇可能会对其产生不同的不良反应,C组使用的药物可能会增加恶心和呕吐的风险Objective To explore the effects of different vasoactive drugs on the health of mothers and infants undergoing cesarean section under combined spinal epidural anesthesia in severe preeclampsia patients.Methods This study selected 75 severe preeclampsia pregnant women who underwent elective combined block anesthesia for cesarean section at Anqiu Maternal and Child Health Hospital from December 2017 to December 2018 as the study subjects.They were divided into three groups using a random number table method,with 25 cases in each group.Pre injection of different vasoactive drugs is one of the effective methods for treating severe preeclampsia.These drugs include tranexamic acid,sodium nitroprusside,and rabelol.All patients will be followed up to record the changes of maternal blood pressure and heart rate at different time points,and evaluate the blood gas index levels of newborn umbilical artery and umbilical vein.The study aims to compare the effects of three different drugs on mothers and infants.Results Comparing the blood pressure levels of three groups of postpartum women at different time points,it was found that there was no statistically significant difference between the three groups at the 1st,10th,12th,and 15th minutes(P>0.05).However,at the 3rd,5th,and 7th minutes,the blood pressure levels in group C were significantly lower than those in groups A and B,and this difference was statistically significant(P<0.05).These data indicate that different drug use may have different effects on maternal blood pressure levels,and the drugs used in group C may have a certain antihypertensive effect.At the first minute,there was no statistically significant difference between the three groups(P>0.05).However,at the 3rd,5th,7th,10th,12th,and 15th minutes,the heart rate levels in group C were higher than those in groups A and B(P<0.05).In addition,the heart rate level of group B was also higher than that of group A after 5 minutes,and this difference was also statistically significant(P<0.05).These data indicate that th

关 键 词：血管活性药 重度子痫前期 腰硬联合麻醉 剖宫产 母儿健康 

分 类 号：R719.8[医药卫生—妇产科学]