新型膦酸酯类化合物的合成及除草活性  

Synthesis and herbicidal activity of novel phosphonate derivatives

作　　者：王威[1] 刘建超[2] 彭浩[2] 贺红武[2] WANG Wei;LIU Jianchao;PENG Hao;HE Hongwu(State Key Laboratory of Fluorine&Nitrogen Chemicals,Xi’an Modern Chemistry Research Institute,Xi’an 710065,China;Key Laboratory of Pesticide&Chemical Biology of Ministry of Education,College of Chemistry,Central China Normal University,Wuhan 430079,China)

机构地区：[1]西安近代化学研究所氟氮化工资源高效开发与利用国家重点实验室,西安710065 [2]华中师范大学化学学院农药与化学生物学教育部重点实验室,武汉430079

出　　处：《华中师范大学学报（自然科学版）》2023年第5期741-747,共7页Journal of Central China Normal University：Natural Sciences

基　　金：国家重点研发计划项目(2017YFD0200506);国家自然科学基金项目(21877047);陕西省重点研发计划项目(2022GY-167).

摘　　要：为获得具有良好除草活性的新型膦酸酯化合物,基于活性亚结构拼接原理,将呋喃环引入先导结构IV的R位设计合成了8个结构新颖的膦酸酯类化合物,并对其进行了除草活性和杀草谱测试.测试结果表明大部分化合物都具有较高的除草活性,其中化合物V-1在75 g·hm^(-2)(a.i.)的浓度下,对测试杂草的效果与草甘膦相当,显示了具有作为除草剂先导化合物进一步研究的价值.In order to find novel phosphonate derivatives with higher herbicidal activity,based on the fragment combination,a furyl group as R was introduced into structure IV to give eight novel phosphonate compounds.Their herbicidal activities were then evaluated.The results showed that most of the target compounds displayed good herbicidal activity against dicotyledonous weeds.Especially,compound V-1 was comparable with glyphosate against several of the tested weeds at the rate of 75 g·hm^(-2)(a.i.).These compounds could be modified and used as potential compounds of herbicide for further study.

关 键 词：膦酸酯 呋喃 合成 除草活性 

分 类 号：O626.2[理学—有机化学]