核酸介导功能纳米材料的合成方法及应用  

Development of Nucleic Acid-mediated Nanomaterials and Their Applications

作　　者：郝强军 叶子 温蓓[1] 彭汉勇 HAO Qiangjun;YE Zi;WEN Bei;PENG Hanyong(State Key Laboratory of Environmental Chemistry and Ecotoxicology,Research Center for Eco-Environmental Sciences,Chinese Academy of Sciences,Beijing 100085,China;School of Environment,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Hangzhou 310024,China;University of Chinese Academy of Sciences,Beijing 100049,China)

机构地区：[1]中国科学院生态环境研究中心,环境化学与生态毒理学国家重点实验室,北京100085 [2]中国科学院大学杭州高等研究院,环境学院,杭州310024 [3]中国科学院大学,北京100049

出　　处：《高等学校化学学报》2023年第10期62-74,共13页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:22276199)资助。

摘　　要：核酸是一种具有独特性质和结构的生物材料,用作介导功能纳米材料精准合成的模板不仅可以提高对纳米颗粒尺寸、形貌的控制,还能赋予纳米颗粒新的理化性质.本文介绍了核酸介导功能纳米材料定向生长的基本原理,综述了核酸介导纳米材料的合成路线和方法,主要包括还原法、沉淀法和水解法等,总结了核酸介导纳米材料在分子检测、细胞成像、催化降解、药物递送和医疗等领域的应用,并指出了目前存在的问题及未来发展方向,为设计与构建新型功能纳米材料及其应用提供了新思路.Nucleic acid is a powerful building block for functional nanomaterials with extensive physiological function and structural potential.It’s an ideal template to mediate the growth of metal nanoparticles,precisely controlling their size,structure and morphology.In this review,we introduced the mechanism of interaction between nucleic acid and metal ions,and reviewed the methods for synthesizing nanomaterials using the nucleic acid templates.The unique properties of nucleic acid mediated nanoparticles enable their broad application in molecule diagnosis,cell imaging,catalytic degradation,drug delivery and therapy.It provides a new strategy to improve the design and construction of functional nanomaterials and explore their application.

关 键 词：核酸模板 核酸纳米技术 核酸探针 纳米递送 

分 类 号：Q52[生物学—生物化学]