MRI联合血清MBP、FGL2对弥漫性颅脑轴索损伤的诊断价值  

Diagnostic Value of MRI Com bined with Serum MBP and FGL2 for Diffuse Craniocerebral Axonal Injury

作　　者：王琨 于文东 许克宁 王娇娇 WANG Kun;YU Wen-dong;XU Ke-ning;WANG Jiao-jiao(Department of Radiology,Zhangjiakou First Hospital,Zhangjiakou 075000,Hebei Province,China)

机构地区：[1]张家口市第一医院放射科,河北张家口075000

出　　处：《中国CT和MRI杂志》2023年第9期39-41,共3页Chinese Journal of CT and MRI

基　　金：2022年度河北省医学科学研究课题计划(20221898)。

摘　　要：目的探讨磁共振成像(MRI)联合血清髓鞘碱性蛋白(MBP)、凝血酶原酶(FGL2)、对弥慢性颅脑轴索损伤的诊断价值。方法进择2020年2月~2022年2月96例本院接收的疑似弥漫性颅脑轴索损伤患者,对研究对象进行MRI检查,酶联免疫吸附法检测患者血清MBP、FGL2水平,受试者工作特征(ROC)曲线分析血清MBP、FGL2对弥漫性颅脑轴索损伤的诊断价值,评价MRI联合血清MBP、FGL2对弥漫性颅脑轴索损伤的诊断效能。结果MRI检查结果显示,96例研究对象中弥漫性颅脑轴索损伤57例、非弥漫性颅脑轴索损伤39例,MRI诊断弥漫性颅脑轴索损伤的灵敏度为80.95%(51/63),特异度为81.82%(27/33),准确度为81,25%(78/96),误诊率为18.18(6/33),漏诊率19.05%(12/63)。与非弥漫性颅脑轴索损伤患者比较,弥漫性颅脑轴索损伤患者血清MBP与FGL2表达水平显著升高,差异有统计学意义(P<0.05)。血清M BP诊断弥漫性颅脑轴索损伤的曲线下面积为0.866(95%CI:0.782~0.927),灵敏度为71.43%,特异度为93,94%,截断值为1.43ng/mL;血清FGL2诊断弥漫性颅脑轴索损伤的曲线下面积为0.820(95%CI:0.728~0.891),灵敏度为73.02%,特异度为87.88%,截断值为82.29ng/mL。MRI、血清MBP、FGL2联合诊断弥漫性颅脑轴索损伤的灵敏度为84.13%、特异度为81.82%,准确度为83.33%。结论MRI联合血清MBR、FGL2对弥漫性颅脑轴索损伤的诊断效能较高,临床应用价值较大。Objective To investigate the diagnostic value of magnetic resonance imaging(MRI)combined with serum myelin basic protein(MBP)and thrombinogenase(FGL2)for diffuse craniocerebral axonal injury.Methods 96 suspected diffuse axonal injury patients admitted to our hospital from February 2020 to February 2022 were selected,MRI was performed on the subjects.Serum MBP and FGL2 levels were detected by enzymelinked immunosorbent assay,the diagnostic value of serum MBP and FGL2 in diffuse craniocerebral axonal injury was analyzed by ROC curve,the diagnostic efficacy of MRI combined with serum MBP and FGL2 in diffuse craniocerebral axonal injury was evaluated.Results MRI examination showed that 57 cases of diffuse craniocerebral axonal injury and 39 cases of non diffuse craniocerebral axonal injury were included in 96 subjects.The sensitivity,specificity,accuracy,misdiagnosis rate and missed diagnosis rate of MRI for diffuse craniocerebral axonal injury were 80.95%(51/63),81.82%(27/33),81.25%(78/96),18.18(6/33)and 19.05%(12/63)respectively.Compared with patients with non diffuse craniocerebral axonal injury,the expression levels of MBP and FGL2 in serum of patients with diffuse craniocerebral axonal injury were significantly higher(P<0.05).The area under the curve of serum MBP in diagnosing diffuse craniocerebral axonal injury was 0.866(95%CI:0.782-0.927),the sensitivity was 71.43%,the specificity was 93.94%,and the cut-off value was 1.43 ng/mL;the area under the curve of serum FGL2 in diagnosing diffuse craniocerebral axonal injury was 0.820(95%CI:0.728-0.891),the sensitivity was 73.02%,the specificity was 87.88%,and the cut-off value was 82.29 ng/mL.The sensitivity,specificity and accuracy of the combination of MRI,serum MBP and FGL2 in the diagnosis of diffuse craniocerebral axonal injury were 84.13%,81.82%and 83.33%respectively.Conclusion MRI combined with serum MBP and FGL2 has high diagnostic efficacy and clinical value for diffuse cranial axonal injury.

关 键 词：磁共振成像 髓鞘碱性蛋白 凝血酶原酶 弥漫性颅脑轴索损伤 诊断 

分 类 号：R445.2[医药卫生—影像医学与核医学]