CT血管造影结合血清Klotho和FGF23水平对冠脉临界病变血管狭窄程度的诊断价值  

Diagnostic Value of CT Angiography Combined with Serum Klotho and FGF23 Levels for the Degree of Coronary Artery Stenosis in Critical Coronary Lesions

作　　者：顾湘 姚倩东[1] 何禹宏 GU Xiang;YAO Qian-dong;HE Yu-hong(Department of Radiology,Sichuan Science City Hospital,Mianyang 621000,Sichuan Province,China;Department of Radiology,Mianyang Central Hospital,Mianyang 621000,Sichuan Province,China)

机构地区：[1]四川省科学城医院放射科,四川绵阳621000 [2]绵阳市中心医院放射科,四川绵阳621000

出　　处：《中国CT和MRI杂志》2023年第9期91-93,共3页Chinese Journal of CT and MRI

基　　金：绵阳市卫生和计划生育委员会资助项目(201726)。

摘　　要：目的分析CT血管造影联合血清Klotho和成纤维细胞生长因子23(FGF23)水平对冠脉临界病变血管狭窄程度的诊断价值。方法选取2021年1月至2022年10月在我院诊治的185例冠脉临界病变患者作为研究对象,以冠拔动脉造影所测狭窄率为金标准,将患者分为轻度狭窄组80例、中重度窄组105例。采用酶联免疫吸附(ELISA)法对患者血清Klotho、FGF23水平进行测定。受试者工作特征(ROC)曲线分析血清Klotho、FGF23水平对冠脉临界病变血管狭窄程度的诊断价值;采用四格表分析CT血管造影联合血清NOX4、Galectin-3水平对冠脉临界病变血管狭窄程度的诊断价值。结果CT血管造影结果显示,冠脉临界病变患者狭窄率<50%有85例,狭窄率≥50%有100例,轻度、中重度狭窄组的符合率分别为87.50%、85.71%;与轻度狭窄组相比,中重度狭窄组冠脉临界病变患者血清Klotho水平明显降低(P<0.05),FGF23水平显著升高(P<0.05);Klotho、FGF23诊断冠脉临界病变血管狭窄程度的曲线下面积(AUC)分别为0.93、0.917;CT血管造影联合血清Klotho、FGF 23水平诊断冠脉临界病变血管狭窄程度的敏感度为95.24%、特异度为85.00%、准确度为90.81%,其诊断效能均高于CT血管造影、血清Klotho、FGF23单独诊断。结论冠脉临界病变中重度狭窄患者血清Klotho水平降低,FGF23水平升高,对冠脉临界病变血管狭窄程度具有一定诊断价值,联合CT血管造影可明显提高冠脉临界病变血管狭窄程度的诊断价值。Objective To analyze the diagnostic value of CT angiography combined with serum Klotho and fibroblast growth factor 23(FGF23)levels on the degree of coronary artery stenosis in critical coronary lesions.Methods A total of 185 patients with critical coronary artery disease diagnosed and treated in our hospital from January 2021 to October 2022 were regarded as the study subjects,the patients were divided into mild stenosis group(80 cases)and moderate severe stenosis group(105 cases)according to the stenosis rate measured by coronary angiography.Enzyme linked immunosorbent assay(ELISA)was used to measure the levels of serum Klotho and FGF23.The diagnostic value of serum Klotho and FGF23 levels for the degree of coronary artery stenosis in patients with critical coronary artery disease was analyzed by ROC curve;the diagnostic value of CT angiography combined with serum NOX4 and Galectin-3 levels for the degree of coronary artery stenosis in critical coronary lesions was analyzed with four grid table.Results CT angiography showed that 85 patients with coronary critical disease had stenosis rate<50%,and 100 patients with stenosis rate≥50%,the coincidence rate in mild and moderate severe stenosis groups was 87.50%and 85.71%respectively;compared with the mild stenosis group,the level of serum Klotho in patients with coronary critical disease in the moderate and severe stenosis group was obviously lower(P<0.05),the level of FGF23 was obviously higher(P<0.05);the area under the curve(AUC)of Klotho and FGF23 in diagnosing the degree of stenosis of coronary artery critical lesion was 0.930 and 0.917 respectively;the sensitivity,specificity and accuracy of CT angiography combined with serum Klotho and FGF23 levels in the diagnosis of coronary artery stenosis in critical coronary lesions were 95.24%,85.00%and 90.81%,respectively,the diagnostic efficacy was higher than that of CT angiography,serum Klotho and FGF23 alone.Conclusion The level of serum Klotho in patients with moderate and severe coronary critical lesion stenosi

关 键 词：冠脉临界病变血管狭窄程度 CT血管造影 KLOTHO FGF23 诊断 

分 类 号：R826.61[医药卫生—临床医学]