钙化性主动脉瓣疾病的发病机制与抗钙化研究进展  

Research progress on pathogenesis and anti-calcification of calcified aortic valve disease

作　　者：赵鹏辉 蔡嘉庚 蔡珠兰 吴岑岑 徐媛 祖凌云[1] Zhao Penghui;Cai Jiageng;Cai Zhulan;Wu Cencen;Xu Yuan;Zu Lingyun(Department of Cardiology,Peking University Third Hospital,NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides,Key Laboratory of Molecular Cardiovascular Sciences,Ministry of Education,Beijing 10019l,China)

机构地区：[1]北京大学第三医院心血管内科、血管医学研究所、血管稳态与重构全国重点实验室、国家卫生健康委心血管分子生物学与调节肽重点实验室、心血管受体研究北京市重点实验室,北京100191

出　　处：《中国医学前沿杂志（电子版）》2023年第9期54-60,共7页Chinese Journal of the Frontiers of Medical Science(Electronic Version)

基　　金：国家重点研发计划项目(2022YFB3807300)。

摘　　要：随着全球老龄化加剧,钙化性主动脉瓣膜疾病(calcified aortic valve disease, CAVD)已成为继冠心病、高血压之后的第三大心血管疾病。以往认为CAVD是一种退行性病变,但最新的研究提示该病的进展是一个主动的、可调节的过程。CAVD的具体发病机制仍不明确,考虑到瓣膜钙化是多种分子及机制共同参与的复杂过程,本文就主动脉瓣钙化的发病机制及抗钙化的研究进展作一综述。With theintensification of global aging,calcified aortic valvedisease(CAVD)hasbecomethethird largest cardiovascular disease after coronary heart disease and hypertension.In the past,CAVD was considered a degenerative disease,but the latest research suggested that the progress of CAVD was an active and adjustable process.However,the specific pathogenesis of CAVD was still elusive.Considering that valve calcification was a complex process involved multiple molecules and mechanisms,this article reviewed the research progress of molecular biology mechanisms of aortic valve calcification and anti-calcification.

关 键 词：主动脉瓣 钙化 抗钙化 发病机制 

分 类 号：R542.52[医药卫生—心血管疾病]