儿童脊柱朗格汉斯细胞组织细胞增生症研究进展  

Research progress on Langerhans cell histiocytosis with spinal involvement in children

作　　者：王玉亭 孙琳[1] 贾海亭 WANG Yuting;SUN Lin;JIA Haiting(National Center for Children's Health,Department of Orthopedics,Beijing Children's Hospital,Capital Medical University,Beijing 100045,China;Department of Orthopaedic Trauma Surgery,Children's Hospital Affiliated to Shandong University,Jinan 250022,China)

机构地区：[1]国家儿童医学中心首都医科大学附属北京儿童医院骨科,北京100045 [2]山东大学附属儿童医院骨科创伤外科,济南250022

出　　处：《中国研究型医院》2023年第4期63-66,共4页Chinese Research Hospitals

摘　　要：朗格汉斯细胞组织细胞增生症(LCH)是一类好发于儿童的组织细胞增殖性疾病,其发病机制尚不明确,临床最常见类型为嗜酸性肉芽肿(EG),常累及多系统或多病灶的骨病。脊柱EG占所有骨EG的6.5%~25.0%。该病后续可能会导致脊柱畸形、神经功能障碍等症状;早期诊治对患儿预后具有重要价值,但关于其早治疗及随访方案尚无共识。因此,就脊柱LCH的流行病学特点、发病机制、临床表现、影像特征、病理检查、临床治疗、预后及随访进行综述,旨在提高临床医师对本病的认识和诊治水平。Langerhans cell histiocytosis(LCH)is a proliferative disease of histiocytic that primarily affects children.The pathogenesis of this disease is not yet clear,and the most common clinical type is eosinophilic granuloma(EG),which often involves multiple systems or multiple bone lesions.Spinal EG accounts for 6.5%to 25.0%of all bone EGs.The disease may lead to spinal deformities,neurological dysfunction,and other symptoms in the later stages.Early diagnosis and treatment are important for the prognosis of affected children,but there is no consensus on early treatment and follow-up strategies.Therefore,this review conducts on the epidemiological characteristics,pathogenesis,clinical manifestations,imaging features,pathological examination,clinical treatment,prognosis,and follow-up of spinal LCH,aimed at improving the understanding and diagnostic and treatment levels of clinical physicians regarding this disease.

关 键 词：儿童 组织细胞增生症 朗格汉斯细胞 脊柱疾病 

分 类 号：R725.5[医药卫生—儿科]