1H-吲哚亚甲基氨基硫脲席夫碱铜(Ⅱ)配合物及其涂层的抗菌性研究  

Antibacterial Properties of Indole Methyl Thiosemicarbazone Copper(Ⅱ)Complex and Its Coating

作　　者：郝豫刚 杨亚良 曾超 Hao Yugang;Yang Yaliang;Zeng Chao(School of Materials and Chemical Engineering,Ningbo University,Ningbo,Zhejiang 315211,China;Key Laboratory of Marine New Materials and Applied Technology,Ningbo Institute of Materials Technology and Engineering,Chinese Academy of Sciences,Ningbo,Zhejiang 315201,China;Zhejiang UTOP New Material Co.,Ltd.,Taizhou,Zhejiang 317500,China)

机构地区：[1]宁波大学材料与化工学院,浙江宁波315211 [2]中国科学院宁波材料技术与工程研究所海洋新材料与应用技术重点实验室,浙江宁波315201 [3]浙江鱼童新材料股份有限公司,浙江台州317500

出　　处：《涂料工业》2023年第10期15-22,共8页Paint & Coatings Industry

基　　金：浙江领雁项目(2022C1213)。

摘　　要：选用具有生物活性的吲哚-3-甲醛与氨基硫脲制备了席夫碱及其铜(Ⅱ)配合物,通过核磁共振氢谱、红外及紫外光谱等手段鉴定了其结构并确认配合物的配位方式。选用金黄色葡萄球菌(S. aureus)与大肠埃希氏菌(E. coli)测试了席夫碱及其铜(Ⅱ)配合物的抗菌性。结果表明:所制备的铜(Ⅱ)配合物对革兰氏阳性与革兰氏阴性菌均具有较好的抗菌效果,对金黄色葡萄球菌(S. aureus)和大肠埃希氏菌(E. coli)的最小抗菌浓度分别为0.40 g/L和0.95 g/L,具备广谱抗菌性。以吲哚甲醛氨基硫脲席夫碱铜(Ⅱ)配合物作为抗菌剂制备的抗菌涂层同样具有良好的抗菌效果,质量分数为5%时就能够杀灭抗菌涂层上黏附的大肠埃希氏菌(E. coli)。通过电镜观察细菌形貌推测吲哚甲醛氨基硫脲席夫碱铜(Ⅱ)配合物可能通过直接作用于细胞膜将其杀灭,具有较优的抗菌性。In this paper,the Schiff base and its copper complex were synthesized using biologically active indole-3-fromaldehyde and aminothiourea.The structure of the prepared Schiff base and the coordinated mode of the copper(Ⅱ)complex were identified by 1H NMR,FT-IR and UV spectroscopy.The antibacterial properties of products were testd using Staphylococcus aureus(S.aureus)and Escherichia coli(E.coli).The results showed that the prepared copper(Ⅱ)complex had a good antibacterial effect on both gram-positive and gramnegative bacteria,and had a minimum inhibitory concentration of 0.40 g/L and 0.95 g/L for S.aureus and E.coli respectively,demonstrating broad-spectrum antimicrobial properties.The coating using indole methyl thiosemicarbazone copper(Ⅱ)complex as antibacterial agent also showed excellent antibacterial performance,which could kill the attached E.coli on the coating surface when 5%of copper complex was contained.Based on bacterial morphology observation by electron microscope,it could be speculated that the copper(Ⅱ)complex killed bacteria by directly acting on the cell membrane,showing good antibacterial performance.

关 键 词：吲哚甲醛 氨基硫脲 配合物 席夫碱 抗菌 

分 类 号：TQ637.3[化学工程—精细化工]