HSP患儿血清25(OH)D、PTX3和IL-1β水平与疾病的关系及临床应用研究  

A Study of Serum 25(OH)D,PTX3 and IL-1βin Children with HSP and Their Relationships with Diseases and Related Clinical Applications

作　　者：付艳华 高宁[2] FU Yanhua;GAO Ning(Department of Rheumatology and Immunology,Baoding Hospital,Beijing Children’s Hospital Affiliated to Capital Medical University,Baoding 071051,China;Department of Pediatrics,Baoding First Central Hospital,Baoding 071000,China)

机构地区：[1]首都医科大学附属北京儿童医院保定医院风湿免疫科,河北保定071051 [2]保定市第一中心医院儿科,河北保定071000

出　　处：《标记免疫分析与临床》2023年第7期1113-1117,共5页Labeled Immunoassays and Clinical Medicine

基　　金：河北省2020年度医学科学研究课题(编号:20200274)。

摘　　要：目的探讨过敏性紫癜(HSP)患儿血清25-羟维生素D[25(OH)D]、正五聚蛋白3(PTX3)和白介素-1β(IL-1β)水平与疾病的关系。方法选取我院2019年9月至2021年9月收治的90例HSP患儿作为HSP组,另选取同期来我院健康体检的儿童90例作为对照组,比较各组血清25(OH)D、PTX3、IL-1β水平,对影响HSP患儿发生紫癜性肾炎进行单因素和多因素分析,Pearson相关系数分析血清25(OH)D、PTX3、IL-1β水平之间的相关性。结果HSP组血清25(OH)D水平低于对照组,血清PTX3、IL-1β高于对照组(P<0.05);C组血清25(OH)D水平低于A组和B组,血清PTX3、IL-1β高于A组和B组(P<0.05),A组和B组血清25(OH)D、PTX3、IL-1β水平差异无统计学意义(P>0.05);发生紫癜性肾炎组与未发生紫癜性肾炎组的性别、年龄、体质指数、血管神经性水肿、上呼吸道感染史差异无统计学意义(P>0.05),反复皮疹、腹痛、关节痛、血清25(OH)D、PTX3、IL-1β水平差异有统计学意义(P<0.05);Logistic回归分析结果显示,反复皮疹、25(OH)D降低、PTX3升高、IL-1β升高是影响HSP患儿发生紫癜性肾炎的独立危险因素(P<0.05);Pearson相关性分析结果显示,25(OH)D与PTX3和IL-1β呈显著负相关(r=-0.523,r=-0.021,P<0.05)。结论HSP患儿血清25(OH)D水平下降,PTX3、IL-1β水平升高,且表达水平与疾病严重程度具有相关性,对病情监测具有重要作用。Objective To investigate serum 25 hydroxyvitamin D[25(OH)D],n-pentamerin 3(PTX3)and interleukin-1β(IL-1β)in children with Henoch-Schonlein purpura(HSP)and their relationships with disease.Methods 90 children with HSP admitted to our hospital from September,2019 to September,2021 were selected as the HSP group,while 90 children who visited our hospital for physical examination during the same period were selected as the control group.Serum 25(OH)D,PTX3 and IL-1βof each group were compared.Single factor and multi-factor analyses were carried out for HSP children with purpura nephritis,and Person correlation coefficient was used to analyze serum 25(OH)D,PTX3,and IL-1βcorrelations.Results Serum 25(OH)D level in HSP group was lower than that in the control group,while serum PTX3,IL-1βwere higher than the control group(P<0.05);Serum 25(OH)D level in group C was lower than that in group A and group B.No significant difference was found for serum PTX3 and IL-1β,when compared with group A and B(P<0.05),also serum 25(OH)D,PTX3,IL-1 in group A and B(P>0.05);There was no significant difference in gender,age,body mass index,angioneurotic edema and history of upper respiratory tract infection between the purpura nephritis group and the non-purpura nephritis group(P>0.05).Repeated rash,abdominal pain,arthralgia,serum 25(OH)D,PTX3,and IL-1βshowed statistically significant difference(P<0.05);Logistic regression analysis showed that repeated rash,25(OH)D decreased,PTX3 increased,and IL-1βelevation were independent risk factors for Henoch-Schonlein purpura nephritis in children with HSP(P<0.05);Pearson correlation analysis showed that 25(OH)D was related to PTX3 and IL-1β,with a significant negative correlation(r=-0.523,r=-0.021,P<0.05).Conclusion Serum 25(OH)D levels in children with HSP decrease,while PTX3 and IL-1βincrease.Changes of levels are correlated with the severity of the disease,which can play an important role in disease monitoring.

关 键 词：过敏性紫癜 25-羟维生素D 正五聚蛋白3 白介素-1Β 疾病严重程度 

分 类 号：R544.6[医药卫生—心血管疾病]