3D打印TPU/PCL共混物食管支架在食管内的生物力学性能  

Biomechanical Properties of 3D Printed TPU/PCL Blends for Esophageal Stents in the Esophagus

作　　者：于鹏 韦归鸿[1] 黄圣华 张麒麟 冯军 曾博 Yu Peng;Wei Guihong;Huang Shenghua;Zhang Qilin;Feng Jun;Zeng Bo(School of Civil Engineering and Architecture,Guangxi University,Nanning 530004,China;Scientific Research Center of Engineering Mechanics,Guangxi University,Nanning 530004,China;Guangxi Nanning Ruifeng Medical Devices Co.,Ltd.,Nanning 530004,China;Department of Thoracic Surgery,the First Affiliated Hospital,Sun Yat-sen University,Guangzhou 510080,China)

机构地区：[1]广西大学土木建筑工程学院,南宁530004 [2]广西大学工程力学研究中心,南宁530004 [3]广西南宁锐锋医疗器械有限公司,南宁530004 [4]中山大学附属第一医院胸外科,广州510080

出　　处：《工程塑料应用》2023年第9期123-129,共7页Engineering Plastics Application

基　　金：广西南宁市技术创新引导专项项目(20204122);广西高校引进海外高层次人才“百人计划”项目。

摘　　要：通过静态和动态的有限元数值模拟及体外力学试验,研究不同组分比的3D打印热塑性聚氨酯(TPU)/聚己内酯(PCL)共混物支架与食管模型之间的生物力学特性,实现对支架植入后食管生物力学表征的预测。采用Abaqus软件对支架植入释放、吞咽收缩和动态迁移过程进行有限元模拟,结合力学试验,对食管模型的收缩率、抗迁移力和管壁应力等指标进行量化、比较和分析。结果表明该支架具有良好的径向性能,能在吞咽压力下保持正常形状且无较大变形,而且比商用食管支架对食管产生的最大等效应力小,可以缓解患者的不适。有限元模拟结果与试验结果吻合度较好。使用有限元方法结合3D打印技术可以快速模拟支架的生物力学性能,并反馈到支架的设计上,优化3D打印共混物支架的制造参数。通过有限元模拟真实的生物力学环境,可以更直观地体现支架植入的治疗效果,为支架的设计和临床选择提供科学的建议。The mechanical properties between 3D printed thermoplastic polyurethane(TPU)/Poly-ε-caprolactone(PCL)blended esophageal stents with different component ratios and esophageal model were investigated by static and dynamic finite element numerical simulations and in vitro mechanical tests to predict the biomechanical characteristics of the esophagus after stent implantation.The finite element simulations of stent implantation release,swallowing contraction and dynamic migration process were established by Abaqus,combined with mechanical tests to quantify,compare and analyze the contraction rate,migration resistance and wall stress of the esophageal model.The results show that the stent has good mechanical properties and can maintain normal shape without large deformation under swallowing pressure,and can alleviate patient discomfort by exerting less equivalent stress on the esophagus than commercial esophageal stents.The finite element simulation results are in good agreement with the experimental results.The biomechanical properties of stents can be rapidly simulated by using finite element method combined with 3D printing technology,which can be fed back to the design of stents and optimize the manufacturing parameters of 3D printing polymer stents.The finite element simulation of the real biomechanical environment can reflect the therapeutic effect of stent implantation more intuitively and provide scientific suggestions for stent design and clinical selection.

关 键 词：有限元法 3D打印 共混物食管支架 生物力学 

分 类 号：TQ317.3[化学工程—高聚物工业]