普罗帕酮与银杏叶提取物在大鼠体内药动学的相互影响  

Pharmacokinetic interactions between propafenone and Ginkgo biloba extract in rats

作　　者：银仁拔 高分飞 杨佩璇[3] 姚欣颖 YIN Renba;GAO Fenfei;YANG Peixuan;YAO Xinying(Pharmacy Intravenous Admixture Services,the First Affiliated Hospital of Shantou University Medical College,Shantou 515041,China;Department of Pharmacology,Shantou University Medical College,Shantou 515041,China;Family Medicine Centre,the First Affiliated Hospital of Shantou University Medical College,Shantou 515041,China)

机构地区：[1]汕头大学医学院第一附属医院静脉药物调配中心,广东汕头515041 [2]汕头大学医学院药理学教研室,广东汕头515041 [3]汕头大学医学院第一附属医院全科医学分院,广东汕头515041

出　　处：《汕头大学医学院学报》2023年第3期129-134,共6页Journal of Shantou University Medical College

摘　　要：目的:观察普罗帕酮和银杏叶提取物联合用药在SD大鼠体内药动学的相互影响。方法:将18只雄性SD大鼠随机分为普罗帕酮组(30 mg/kg)、银杏叶提取物组(10.5 mg/kg)、联合用药组(普罗帕酮30 mg/kg,银杏叶提取物10.5 mg/kg)。连续给药6 d,第7天各组给药剂量减半后在不同时间点(5 min、0.25、0.5、1、1.5、2、4、6、8、12、24 h)于颈静脉采血。利用液相色谱-串联质谱法测定血浆中普罗帕酮及银杏叶提取物的有效成分(槲皮素、山奈酚、异鼠李素)的浓度,通过WinNonlin 8.1软件计算药动学参数。结果:与普罗帕酮组相比,联合给药组普罗帕酮的曲线下面积(AUC0-t、AUC0-∞)、药峰浓度(cmax)降低,清除率升高(P<0.05)。与银杏叶提取物组相比,联合给药组槲皮素的AUC0-∞增加(P<0.05),山奈酚和异鼠李素的药动学参数均无明显变化(P>0.05)。结论:普罗帕酮与银杏叶提取物联合用药后普罗帕酮在大鼠体内的消除加快。Objective:To investigate the pharmacokinetic interactions of the combination of propafenone and Ginkgo biloba extract in SD rats.Methods:Eighteen male SD rats were randomly divided into the propafenone group(30 mg/kg),the Ginkgo biloba extract group(10.5 mg/kg),and the drug combination group(propafenone 30 mg/kg,Ginkgo biloba extract 10.5 mg/kg).The drugs were administered continuously for 6 d.Blood was collected from the jugular vein at different time points(5 min,0.25,0.5,1,1.5,2,4,6,8,12,and 24 h)on the 7th day after the dose of each group was halved.The concentrations of propafenone and active ingredients of Ginkgo biloba extract(quercetin,kaempferol,isorhamnetin)in plasma were determined by liquid chromatography-tandem mass spectrometry,and pharmacokinetic parameters were calculated by WinNonlin 8.1 software.Results:The area under the curve(AUC0-t,AUC0-∞)and peak concentration(cmax)of propafenone decreased and clearance increased in the combination group compared to the propafenone group(P<0.05).The AUC0-∞of quercetin was increased in the combination group compared to the Ginkgo biloba extract group(P<0.05),and there were no significant changes in the pharmacokinetic parameters of both kaempferol and isorhamnetin(P>0.05).Conclusion:The elimination of propafenone in rats was accelerated after the combination of propafenone and Ginkgo biloba extract.

关 键 词：普罗帕酮 银杏叶提取物 联合用药 药动学 

分 类 号：R969.1[医药卫生—药理学]