甲泼尼龙片联合阿托伐他汀钙对慢性硬膜下血肿钻孔引流术疗效的影响  

Effect of methylprednisolone tablets combined with atorvastatin calcium on the efficacy of drilling and drainage of chronic subdural hematoma

作　　者：黄亿平 李汉城[2] 洪映标[2] 许宏武[1] HUANG Yiping;LI Hancheng;HONG Yingbiao;XU Hongwu(Department of Neurosurgery,the First Affiliated Hospital of Shantou University Medical College,Shantou 515041,China;Department of Neurosurgery,Jieyang Peoples Hospital,Jieyang 522000,China)

机构地区：[1]汕头大学医学院第一附属医院神经外科,广东汕头515041 [2]揭阳市人民医院神经外科,广东揭阳522000

出　　处：《汕头大学医学院学报》2023年第3期161-163,168,共4页Journal of Shantou University Medical College

基　　金：揭阳市卫生医疗科技创新项目(ylxm018)。

摘　　要：目的:探讨慢性硬膜下血肿经钻孔引流术后予甲泼尼龙片联合阿托伐他汀钙治疗的临床疗效。方法:回顾性分析2021年7月—2022年12月揭阳市人民医院收治的104例慢性硬膜下血肿患者的临床资料。按照钻孔引流术后用药的不同,分为观察组(甲泼尼龙片联合阿托伐他汀钙组)和对照组(阿托伐他汀钙组)。比较两组的二次手术和并发症的发生率、住院时间、总费用。结果:观察组30例,其中男性26例,女性4例,年龄(68.3±13.3)岁。对照组74例,其中男性55例,女性19例,年龄(70.8±9.2)岁。两组患者的性别、年龄差异无统计学意义(均P>0.05)。观察组二次手术、并发症的发生率(分别为3.3%、6.7%)低于对照组(分别为18.9%和24.3%),差异有统计学意义(均P<0.05)。结论:慢性硬膜血肿患者经钻孔引流术后,口服甲泼尼龙片联合阿托伐他汀钙,可降低二次手术和并发症的发生率。Objective:To investigate the clinical efficacy of methylprednisolone tablets combined with atorvastatin calcium in the treatment of chronic subdural hematoma after drilling and drainage.Methods:The clinical data of 104 patients with chronic subdural hematoma admitted to Jieyang Peoples Hospital from July 2021 to December 2022 were retrospectively analyzed.They were divided into observation group(methylprednisolone tablets combined with atorvastatin calcium group)and control group(atorvastatin calcium group)according to the different medications used after drilling and drainage.The incidence of secondary surgery and complications,hospitalization time,and total cost were compared between the two groups.Results:There were 30 cases in the observation group,including 26 males and 4 females,aged(68.3±13.3)years.There were 74 cases in the control group,including 55 males and 19 females,aged(70.8±9.2)years.There was no statistically significant difference in gender and age between the two groups(all P>0.05).The incidence of secondary surgery and complications in the observation group(3.3%and 6.7%,respectively)was lower than that in the control group(18.9%and 24.3%,respectively),and the difference was statistically significant(all P<0.05).Conclusion:Oral methylprednisolone tablets combined with atorvastatin calcium after drilling and drainage in patients with chronic subdural hematoma reduces the incidence of secondary surgery and complications.

关 键 词：慢性硬膜下血肿 甲泼尼龙 阿托伐他汀钙 钻孔引流术 

分 类 号：R651[医药卫生—外科学]