血清超敏C反应蛋白/白蛋白比率与中性粒细胞/淋巴细胞比率在小儿支气管肺炎病情评估中的应用价值  

Application Value of Serum High-Sensitivity C-Reactive Protein/Albumin Ratio and Neutrophil/Lymphocyte Ratio in the Assessment of Pediatric Bronchopneumonia

作　　者：朱丽华[1] 阴晴[1] 朱波[1] ZHU Li-hua;YIN Qing;ZHU Bo(Department of Laboratory Medicine,Affiliated Hospital of Jiangsu University,Zhenjiang,Jiangsu,212001,China)

机构地区：[1]江苏大学附属医院检验科,江苏镇江212001

出　　处：《中国血液流变学杂志》2023年第2期258-261,共4页Chinese Journal of Hemorheology

基　　金：国家自然科学基金青年项目(81701612)。

摘　　要：目的探讨血清C反应蛋白/白蛋白比率(CAR)和中性粒细胞/淋巴细胞比率(NLR)在小儿支气管肺炎病情评估中的应用。方法收集200例小儿支气管肺炎患者临床资料,将所有患者根据其病情严重程度分为轻度组(n=96)、中重度组(n=104),并选取同期健康体检的48名儿童设为对照组,检测并对比轻度组与中重度组CAR、NLR水平,分析CAR、NLR在小儿支气管肺炎病情评估中的应用价值。结果支气管肺炎患儿中性粒细胞绝对数及C反应蛋白水平明显高于对照组,差异有统计学意义(P均<0.001),而中重度组与轻度组相比,两组间中性粒细胞绝对数及C反应蛋白水平差异无统计学意义(P均>0.05);中重度组CAR及NLR水平显著高于轻度组,差异有统计学意义(P<0.01,P<0.05)。受试者工作特征曲线分析表明,CAR和NLR评估支气管肺炎病情严重的曲线下面积(AUC)分别为0.902和0.761,当Cut off值分别为0.42和2.36时,评估支气管肺炎病情严重的敏感性分别为0.85和0.73,特异性为0.76和0.68。结论CAR和NLR水平与小儿支气管肺炎病情具有一定的相关性,对小儿支气管肺炎病情评估有一定价值。Objective To investigate the application of serum C-reactive protein/albumin ratio(CAR)and neutrophil/lymphocyte ratio(NLR)in the assessment of pediatric bronchopneumonia.Methods Clinical data of 200 children with bronchopneumonia were collected,and all the children were divided into mild group(n=96)and moderate-severe group(n=104)according to the severity of their illness,and 48 children who had undergone physical examination during the same period were selected as the control group,the levels of CAR and NLR in the mild group and moderate-severe group of bronchopneumonia were detected and compared,and the application value of CAR and NLR in the evaluation of pediatric bronchopneumonia was analyzed.Results The absolute number of neutrophils and the level of CRP in pediatric bronchopneumonia were significantly higher than those in the control group,and the difference was statistically significant(P<0.001).There were no significant differences in absolute numbers of neutrophils and CRP levels(all P>0.05),but the levels of CAR and NLR in children with moderate and severe bronchopneumonia were significantly higher than those in the mild group,and the differences were statistically significant(P<0.01,P<0.05).The receiver operating characteristic curve analysis showed that the area under the curve(AUC)of CAR and NLR to assess the severity of bronchopneumonia were 0.902 and 0.761,respectively.When the cut off values were 0.42 and 2.36,respectively,the sensitivity for assessing the severity of bronchopneumonia was 0.85 and 0.73,specificity was 0.76 and 0.68.Conclusion The levels of CAR and NLR have a certain correlation with the severity of pediatric bronchitis,and have certain value in the assessment of the severity of pediatric bronchitis.

关 键 词：小儿支气管肺炎 C反应蛋白/白蛋白比率 中性粒细胞/淋巴细胞比率 病情评估 炎症指标 

分 类 号：R446.11[医药卫生—诊断学]