空肠弯曲杆菌血流感染报道1例  

A case of bloodstream infection caused by Campylobacter jejuni

作　　者：熊丽娟 郭建[2] XIONG Lijuan;GUO Jian(Department of Laboratory Medicine,the Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine,Guiyang 550001,Guizhou Province,China;Department of Laboratory Medicine,Shanghai East Hospital,Tongji University School of Medicine,Shanghai 200120,China)

机构地区：[1]贵州中医药大学第二附属医院检验科,贵州贵阳550001 [2]上海市东方医院南院检验科,上海200120

出　　处：《微生物与感染》2023年第2期97-101,共5页Journal of Microbes and Infections

基　　金：上海市浦东新区卫生系统重点学科建设资助项目(PWZXK2017-09)。

摘　　要：本文报道了空肠弯曲杆菌血流感染1例,并研究了其生物学特性与可能存在的耐药基因,为临床有效治疗相关疾病提供科学的实验室依据。采用常规方法、基质辅助激光解吸电离飞行时间质谱分析、测序分析和聚合酶链反应(polymerase chain reaction,PCR)等技术,对从1位老年女性血液中分离出的1株致病菌进行菌种鉴定、药物敏感试验、耐药基因检测等。结果显示,此分离菌株为空肠弯曲杆菌,其对环丙沙星、四环素耐药,对红霉素敏感。采用PCR检测出空肠弯曲杆菌的3种耐药基因gyrA、gyrB、tex(O),可能与其药敏试验结果相关。A case of bloodstream infection caused by Campylobacter jejuni was reported,and its biological characteristics and possible drug resistance genes was studied to provide scientific laboratory basis for effective clinical treatment of related diseases.The strain isolated from the blood of an elderly female was identified by conventional methods,matrix-assisted laser desorption ionization time of flight mass spectrometry(MALDI-TOFMS),sequencing and polymerase chain reaction(PCR).Results show that the isolated strain was Campylobacter jejuni,and it was resistant to ciprofloxacin and tetracycline and sensitive to erythromycin.Three drug resistance genes gyrA,gyrB and tex(O)in Campylobacter jejuni were detected by PCR,which may be related to the results of drug sensitivity test.

关 键 词：空肠弯曲杆菌 血流感染 耐药基因 

分 类 号：R372[医药卫生—病原生物学] R378[医药卫生—基础医学]