中性粒细胞胞外诱捕网与细菌相互作用机制的研究进展  

Advances in mechanisms of interactions between neutrophil extracellular traps and bacteria

作　　者：龚亚婷 曹宇 吴淑燕[1] 黄瑞[1] GONG Yating;CAO Yu;WU Shuyan;HUANG Rui(School of Biology&Basic Medical Sciences,Medical College of Soochow University,Suzhou 215123,Jiangsu Province,China)

机构地区：[1]苏州大学医学部基础医学与生物科学学院,江苏苏州215123

出　　处：《微生物与感染》2023年第2期106-114,共9页Journal of Microbes and Infections

基　　金：国家自然科学基金面上项目(81971899、31670140)。

摘　　要：在抗感染免疫过程中,中性粒细胞可通过释放中性粒细胞胞外诱捕网(neutrophil extracellular trap,NET)捕获并杀伤病原体。NET是一把“双刃剑”,一方面可维持机体稳态,另一方面NET过量或清除不及时会导致一些疾病的发生。细菌诱导和抵御NET的机制不尽相同,本文就NET的生成和释放及其在细菌感染过程中的作用进行综述。Neutrophils can capture and kill pathogens by releasing neutrophil extracellular trap(NET)during anti-infection immunity.NET is a double-edged sword.On the one hand,it can maintain the homeostasis of the body;on the other hand,excessive NET or delayed removal may lead to the occurrence of some diseases.The mechanisms by which bacteria induce and resist NET are different.This article reviews the formation and release of NET and their roles in bacterial infection.

关 键 词：抗感染免疫 中性粒细胞胞外诱捕网 细菌 

分 类 号：R378[医药卫生—病原生物学] R392[医药卫生—基础医学]