醒脑开窍针刺法治疗产后抑郁的临床疗效  

Clinical Effect of Xingnao Kaiqiao Acupuncture on Postpartum Depression

作　　者：王强玉 张海彦 谢安妮 李新华 WANG Qiang-yu;ZHANG Hai-yan;XIE An-ni;LI Xin-hua(Department of Acupuncture,Shijiazhuang Maternal and Child Healthcare Hospital,Shijiazhuang 050000,China;Teaching and Research Department,College of Acupuncture-Moxibustion and Tuina,Hebei University of Chinese Medicine,Shijiazhuang 050000,China)

机构地区：[1]石家庄市妇幼保健院针灸科,050000 [2]河北中医药大学针灸推拿学院教研室

出　　处：《国际妇产科学杂志》2023年第5期555-558,共4页Journal of International Obstetrics and Gynecology

基　　金：河北省中医药管理局科研计划项目(2022194)。

摘　　要：目的:探讨醒脑开窍针刺法治疗产后抑郁(postpartum depression,PPD)的效果。方法:选取2022年1—9月石家庄市妇幼保健院收治的PPD患者80例,采用随机数字表法分为2组,每组各40例。对照组给予常规西药治疗,观察组给予醒脑开窍针刺法结合西药治疗,疗程为8周。统计2组患者的疗效、安全性,并比较2组患者治疗前、后的抑郁程度[汉密尔顿抑郁量表(Hamilton Depression Scale,HAMD)、爱丁堡产后抑郁量表(Edinburgh Postnatal Depression Scale,EPDS)]、性激素水平[孕酮(progesterone,P)、雌二醇(estradiol,E2)]和神经递质水平[5-羟色胺(5-hydroxytryptamin,5-HT)、孤啡肽(OFQ)]。结果:观察组的疗效和总有效率均高于对照组,差异有统计学意义(P<0.05);治疗8周后,2组患者的HAMD、EPDS评分及OFQ水平均较治疗前下降,观察组低于对照组,2组P、E2、5-HT水平均较治疗前升高,观察组高于对照组,差异有统计学意义(P<0.05)。结论:醒脑开窍针刺法治疗PPD疗效显著,能改善抑郁相关因子表达,降低抑郁程度,且安全性高。Objective: To investigate the effect of Xingnao Kaiqiao acupuncture on postpartum depression (PPD). Methods: A total of 80 patients with PPD in our hospital were selected from January 2022 to September 2022 and divided into two groups with 40 cases in each group by random number method. The control group was given conventional Western medicine, and the observation group was treated with acupuncture combined with Western medicine. The course of treatment was eight weeks. The therapeutic efficacy and safety of the two groups were analyzed, and the degree of depression [Hamilton Depression Scale (HAMD), Edinburgh Postpartum Depression Scale (EPDS)], sex hormone levels [progesterone (P), estradiol (E2)], neurotransmitter levels [5-hydroxytryptamine (5-HT), orphanin FQ (OFQ)] were compared between the two groups before treatment and eight weeks after treatment. Results: The efficacy of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05). After eight weeks of treatment, the HAMD, EPDS scores and OFQ levels of the two groups decreased compared with those before treatment, and the observation group was lower than the control group;the P, E2 and 5-HT levels of the two groups increased compared with those before treatment, and the observation group was higher than the control group, and the difference was statistically significant (P<0.05). Conclusions: Xingnao Kaiqiao acupuncture has a significant effect on the treatment of PPD, which can improve the expression of depressed-related factors and reduce the degree of depression with high safety.

关 键 词：舍曲林 抑郁症 产后期 血清素 醒脑开窍针刺法 孤啡肽 

分 类 号：R246.3[医药卫生—针灸推拿学]