纳米晶的制备技术及其在黏膜给药系统中的研究进展  

Preparation Technology of Nanocrystals and Research Progress in Mucosal Drug Delivery Systems

作　　者：马月琴 李刚[1] 肖汉扬 岳鹏飞 张增珠 MA Yueqin;LI Gang;XIAO Hanyang;YUE Pengfei;ZHANG Zengzhu(Dept.of Pharmaceutics,908th Hospital of Joint Logistics Support Force of PLA,Nanchang 330000;Key Lab.of Modern Preparation of TCM,Ministry of Education,Jiangxi University of Chinese Medicine,Nanchang 330004)

机构地区：[1]中国人民解放军联勤保障部队第九〇八医院药学科,江西南昌330000 [2]江西中医药大学现代中药制剂教育部重点实验室,江西南昌330004

出　　处：《中国医药工业杂志》2023年第7期1042-1051,共10页Chinese Journal of Pharmaceuticals

摘　　要：纳米晶的制备工艺简单、载药量高、黏附性强,可有效解决水难溶性药物滞留时间短、释放速度慢、生物利用度低等问题,已成为近年来药剂学领域研究的热点。该文就纳米晶的制备技术及其应用于鼻腔、眼部、口腔、皮肤、肺部等黏膜给药系统的研究进展进行综述,以期为难溶性药物纳米晶制剂的研发提供参考依据。Owing to simple preparation process,high drug loading capacity and strong adhesion,nanocrystals can effectively solve the problems of short-term retention time,slow release rate and low bioavailability of poorly watersoluble drugs.Therefore,it has become a hot research topic in pharmaceutics in recent years.In this paper,the preparation technologies of nanocrystals and their research progress of applications in mucosal drug delivery systems such as nasal,ocular,oral,skin and pulmonary delivery systems are reviewed,hoping to provide a reference basis for the development of nanocrystal-based dosage forms of poorly soluble drugs.

关 键 词：水难溶性药物 纳米晶 制备技术 黏膜给药 应用 

分 类 号：R944.9[医药卫生—药剂学]