黄芩素抗肿瘤机制及其纳米递送系统研究进展  

Recent Advances in Antitumor Mechanism of Baicalein and Its Nano Delivery Systems

作　　者：陆林玮 丁源[2] 许倩竹 陆伟跃[2,3] LU Linwei;DING Yuan;XU Qianzhu;LU Weiyue(Dept.of Integrative Medicine,Huashan Hospital,Fudan University,Shanghai 200040;Key Lab.of Smart Drug Delivery(Fudan University),Ministry of Education and PLA,Dept.of Pharmaceutics,School of Pharmacy,Fudan University&Institutes of Integrative Medicine,Fudan University,Shanghai 201203;Dept.of Research and Development,Shanghai Tayzen PharmLab Co.,Ltd.,Shanghai 201314)

机构地区：[1]复旦大学附属华山医院中西医结合科,上海200040 [2]复旦大学药学院药剂学系,智能化递药教育部及全军重点实验室(复旦大学),复旦大学中西医结合研究院,上海201203 [3]上海泰禛生物技术有限公司研发部,上海201314

出　　处：《中国医药工业杂志》2023年第7期1052-1059,共8页Chinese Journal of Pharmaceuticals

基　　金：上海市青年科技英才扬帆计划(20YF1404500);复旦大学附属华山医院科研启动基金项目(2019QD012)。

摘　　要：黄芩素是来源于中药黄芩的一种黄酮类成分,能通过抑制肿瘤细胞生长、诱导肿瘤细胞凋亡、抑制肿瘤血管生成、调节肿瘤微环境等多种途径发挥抗肿瘤作用。然而,其溶解度不高,影响了体内生物利用度和药效。因此,许多研究采用丰富多样的纳米递送策略帮助改善其生物利用度以提升抗肿瘤药效。该文总结了黄芩素抗肿瘤机制及其纳米递送系统,以期为黄芩素的基础研究及临床应用提供参考。Baicalein,a flavone derived from Scutellaria baicalensis,exhibits antitumor effect by suppressing tumor cell proliferation,inducing tumor cell apoptosis,inhibiting tumor angiogenesis,and regulating the tumor microenvironment.However,its poor solubility has attenuated the bioavailability and thus restricting the efficacy.Many studies utilize nano-drug delivery systems to improve bioavailability and antitumor efficacy of baicalein.This review summarizes the recent studies concerning the antitumor mechanisms of baicalein and its nano delivery systems to provide approaches for its further basic research and clinical application.

关 键 词：黄芩素 抗肿瘤机制 生物利用度 纳米递药系统 肿瘤治疗 

分 类 号：R979.1[医药卫生—药品]