小鼠肾缺血再灌注损伤模型的研究进展  

Research progress in mouse models of renal ischemia-reperfusion injury

作　　者：闫聚瀚 赵朋涛 闫晓冬 刘鑫(综述) 李向东(审校)[2] YAN Juhan;ZHAO Pengtao;YAN Xiaodong;LIU Xin;LI Xiangdong(Graduate School,Hebei North University,Zhangjiakou 075000,Hebei,China;The First Affiliated Hospital,Hebei North University,Zhangjiakou 075000,Hebei,China)

机构地区：[1]河北北方学院研究生学院,河北张家口075000 [2]河北北方学院附属第一医院,河北张家口075000

出　　处：《西部医学》2023年第10期1555-1560,共6页Medical Journal of West China

基　　金：河北省中医药管理局科研计划项目(2023096)。

摘　　要：肾脏是发生缺血再灌注损伤(IRI)的重要器官之一,肾IRI是导致急性肾损伤(AKI)的主要原因,是一种伴随着高发病率及高死亡率的肾脏疾病。目前,许多体内、外实验模型已用于缺血性AKI的致病机制和对肾脏保护作用的研究。其中,因小鼠体积小、饲养方便、易控性好、繁殖快等特点,研究者使用夹闭小鼠肾蒂建造肾IRI模型的方法被广泛应用。然而,要想建立良好稳定的小鼠肾IRI模型并不容易,因小鼠对外界刺激极其敏感,常导致实验结果出现一定差异。因此,本文对双侧肾IRI小鼠模型建立的经验和进展作一综述,以此为基础为建立标准肾IRI模型提供一定的参考价值,也为其他研究者建立良好、可靠的肾IRI小鼠模型提供帮助。The kidney is one of the important organs in the occurrence of ischemia-reperfusion injury(IRI).Renal IRI is the main cause of acute kidney injury(AKI).At present,many in vivo and in vitro experimental models have been used to study the pathogenic mechanism and renal protection of ischemic AKI.Among them,due to the characteristics of small size,convenient feeding,good controllability,and fast reproduction of mice,the method of establishing renal IRI models by clipping mouse renal pedicles is widely used.However,it is not easy to establish a good and stable mouse kidney IRI model,because mice are extremely sensitive to external stimuli,which often leads to certain differences in experimental results.Therefore,this paper reviews the experience and progress of the establishment of the bilateral renal IRI mouse model,and based on this,it provides a certain reference value for the establishment of a standard renal IRI model,and also for other researchers to establish a good and reliable renal IRI mouse model provide help.

关 键 词：肾脏缺血再灌注损伤 急性肾损伤 小鼠模型 野生型C57小鼠 

分 类 号：R692.5[医药卫生—泌尿科学]