小青龙颗粒联合布地奈德、硫酸特布他林治疗小儿支气管哮喘的效果  

Effect of Xiaoqinglong Granule combined with Budesonide and Terbutaline Sulfate in the treatment of bronchial asthma in children

作　　者：史永铭 SHI Yongming(Department of Pediatrics,Dehui Hospital of Traditional Chinese Medicine,Jilin Province,Dehui130300,China)

机构地区：[1]吉林省德惠市中医院儿科,吉林德惠130300

出　　处：《中国当代医药》2023年第27期92-96,共5页China Modern Medicine

摘　　要：目的分析小青龙颗粒联合布地奈德、硫酸特布他林治疗小儿支气管哮喘的临床效果。方法选取2021年9月至2022年9月德惠市中医院儿科收治的94例小儿支气管哮喘患儿作为研究对象,按照随机数字表法将其分为研究组(47例)和参照组(47例)。参照组采用西药布地奈德、硫酸特布他林治疗。研究组在参照组基础上加用小青龙颗粒治疗。治疗7 d后,比较两组患儿的临床疗效,并对比其中医证候积分的变化,测定比较两组患儿的基质金属蛋白酶-9(MMP-9)以及白细胞介素17(IL-17)的水平。结果研究组的总有效率高于参照组,差异有统计学意义(P<0.05)。两组患儿治疗前的中医证候积分比较,差异无统计学意义(P>0.05);治疗后,两组患儿的中医证候积分均低于本组治疗前,且研究组低于参照组,差异有统计学意义(P<0.05)。两组患儿治疗前的MMP-9、IL-17水平比较,差异无统计学意义(P>0.05);治疗后,两组患儿的MMP-9、IL-17水平均低于本组治疗前,且研究组低于参照组,差异有统计学意义(P<0.05)。结论采用小青龙颗粒联合布地奈德、硫酸特布他林治疗小儿支气管哮喘,能改善气道炎症和气道重塑,促进中医证候积分的改善,有助于提高临床效果。Objective To analyze the clinical effect of Xiaoqinglong Granule combined with Budesonide and Terbutaline Sulfate in the treatment of bronchial asthma in children.Methods A total of 94 children with bronchial asthma admitted to the Department of Pediatrics,Dehui Hospital of Traditional Chinese Medicine from September 2021 to September 2022 were selected as the research objects.According to the random number table method,they were divided into study group(47 cases)and reference group(47 cases).The reference group was treated with Budesonide and Terbutaline Sulfate.The study group was treated with Xiaoqinglong Granule on the basis of the reference group.After 7 days of treatment,the clinical efficacy of the two groups were compared,and the changes of traditional Chinese medicine syndrome scores were compared.And the levels of matrix metalloproteinase-9(MMP-9)and interleukin-17(IL-17)were measured and compared between the two groups.Results The total effective rate of the study group was higher than that of the reference group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in traditional Chinese medicine syndrome score between the two groups before treatment(P>0.05).After treatment,the traditional Chinese medicine syndrome score of the two groups were lower than those before treatment,and the score of study group was lower than the reference group,and the differences were statistically significant(P<0.05).There were no significant differences in the levels of MMP-9 and IL-17 between the two groups before treatment(P>0.05).After treatment,the levels of MMP-9 and IL-17 in the two groups were lower than those before treatment,and those in the study group were lower than those in the reference group,and the differences were statistically significant(P<0.05).Conclusion Xiaoqinglong Granule combined with Budesonide and Terbutaline Sulfate in the treatment of children with bronchial asthma can improve airway inflammation and airway remodeling,promote the improveme

关 键 词：小儿 支气管哮喘 小青龙颗粒 中西医联合 疗效 

分 类 号：R725.6[医药卫生—儿科]