枸橼酸咖啡因联合经鼻双水平气道正压通气治疗早产儿呼吸暂停的临床效果  

Clinical effect of Caffeine Citrate combined with nasal bi-level positive airway pressure in the treatment of apnea of prematurity

作　　者：刘大伟[1] 高艳[1] LIU Dawei;GAO Yan(Department of Neonatology,Lianyungang Maternal and Child Health Hospital,Jiangsu Province,Lianyungang222000,China)

机构地区：[1]江苏省连云港市妇幼保健院新生儿科,江苏连云港222000

出　　处：《中国当代医药》2023年第27期97-100,共4页China Modern Medicine

摘　　要：目的探讨枸橼酸咖啡因联合经鼻双水平气道正压通气(nBiPAP)治疗早产儿呼吸暂停(AOP)的临床效果。方法选取2019年6月至2022年6月连云港市妇幼保健院收治的80例AOP患儿为研究对象,按照随机数字表法分为对照组和观察组,每组40例。对照组行nBiPAP治疗,基于此,观察组加用枸橼酸咖啡因治疗。比较两组的临床疗效、治疗情况、血气分析指标及并发症发生率。结果观察组治疗总有效率为99.5%,高于对照组的77.5%,差异有统计学意义(P<0.05)。观察组总用氧时间为(6.79±2.03)d,无创呼吸时间为(4.52±1.96)d,住院时间为(18.31±3.97)d,呼吸暂停次数为(1.20±0.25)次/d,呼吸暂停时间为(15.23±2.42)s/次,均短于对照组的(10.15±3.51)d、(6.33±2.49)d、(24.58±5.56)d、(2.21±0.35)次/d、(19.35±3.56)s/次,差异有统计学意义(P<0.05)。两组治疗后的血二氧化碳分压(PCO_(2))低于本组治疗前,pH、血氧分压(PO_(2))高于本组治疗前,且观察组PCO_(2)为(40.38±3.41)mmHg,低于对照组的(45.16±4.67)mmHg,PO_(2)为(78.21±6.96)mmHg,pH为(7.38±0.03),高于对照组的(69.94±5.35)mmHg、(7.34±0.02),差异有统计学意义(P<0.05)。两组的并发症总发生率比较,差异无统计学意义(P>0.05)。结论AOP患儿采用枸橼酸咖啡因联合nBiPAP治疗效果显著,利于缩短治疗时间,改善血气分析指标,且不会增加并发症发生,临床应用安全可靠。Objective To investigate the clinical effect of Caffeine Citrate combined with nasal bi-level positive airway pressure(nBiPAP)on apnea of prematurity(AOP).Methods Eighty children with AOP admitted to Lianyungang Maternal and Child Health Hospital from June 2019 to June 2022 were selected as the study objects,and they were divided into control group and observation group according to random number table method,with 40 cases in each group.The control group received nBiPAP treatment,and based on this,the observation group received additional treatment with Caffeine Citrate.The clinical efficacy,treatment,blood gas analysis index and complication rate of the two groups were compared.Results The total effective rate of the observation group was 99.5%,higher than the 77.5%of the control group,with statistically significant difference(P<0.05).The observation group had an total oxygen usage time of(6.79±2.03)d,non-invasive breathing time of(4.52±1.96)d,hospitalization time of(18.31±3.97)d,apnea frequency of(1.20±0.25)times/d,and apnea time of(15.23±2.42)s/time,all of which were shorter than the control group's(10.15±3.51)d,(6.33±2.49)d,(24.58±5.56)d,(2.21±0.35)times/d,and(19.35±3.56)s/time,with statistically significant differences(P<0.05).Blood partial pressure of carbon dioxide(PCO_(2))after treatment was lower than that before treatment,pH and blood partial pressure of oxygen(PO_(2))were higher than those before treatment,and PCO_(2)in the observation group was(40.38±3.41)mmHg,lower than that in the control group(45.16±4.67)mmHg.PO_(2)was(78.21±6.96)mmHg,pH was(7.38±0.03)higher than that of control group(69.94±5.35)mmHg,pH was(7.34±0.02),the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of complications between the two groups(P>0.05).Conclusion The combination of caffeine citrate and nBiPAP has a significant therapeutic effect on children with AOP,which is beneficial for shortening treatment time,improving blood gas analysis indica

关 键 词：早产儿呼吸暂停 枸橼酸咖啡因 经鼻双水平气道正压通气 血气分析指标 

分 类 号：R722[医药卫生—儿科]