李华山调治便秘型肛肠病用药规律分析  

Analysis on the Medication Rules of LI Huashan in the Treatment of Constipation Type Anorectal Diseases

作　　者：袁润 姜芸 雷沥 田瑞 张株惠 李华山[1] YUAN Run;JIANG Yun;LEI Li;TIAN Rui;ZHANG Zhuhui;LI Huashan(Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China;Graduate School of Beijing University of Chinese Medicine,Beijing 100029,China)

机构地区：[1]中国中医科学院广安门医院,北京100053 [2]北京中医药大学研究生院,北京100029

出　　处：《中医药导报》2023年第9期96-100,120,共6页Guiding Journal of Traditional Chinese Medicine and Pharmacy

摘　　要：目的:基于中医传承辅助平台分析李华山教授诊治便秘型肛肠病的用药规律。方法:筛选李华山教授肛肠病兼夹便秘症状的门诊病历资料,通过中医传承辅助平台V2.5组建便秘兼症门诊病历数据库,归纳患者年龄、西医诊断、中医证型、中药性味归经、核心药物及高频配伍组合。结果:共筛选出217位患者病历信息,年龄呈正态分布,以41~60岁最为多见;调治的肛肠病以混合痔最多,结直肠肿瘤、肠道息肉等频数较高;中医证型以湿热下注证、气滞血瘀证、肝郁脾虚证为主,使用中药47味,频数≥80的中药有17味,用药频数排在前5位的药物为白术、黄芪、生地黄、麦冬、玄参,支持度为140,置信度>90%时有17对关联规则,常用药物组合有麦冬-生地黄-玄参、黄芪-白术、枳壳-白术等,四气以温、寒为主,五味以甘、苦为主。归纳得到黄芪、白术、枳壳等9味核心药物为主,高频药物以补益药、清热药、理气药、泻下药为主,功效以健脾益气养阴、行气活血、润肠通便为主。结论:李华山教授对于便秘型肛肠病的用药重在理气健中,滋阴养血,缓泻润肠。核心药物在治疗伴随便秘症状的混合痔、结直肠肿瘤、结肠息肉等肛肠病中发挥作用,为临床防治常见肛肠病及并发症提供了数据支撑。Objective:To analyze the medication rule of Professor Li Huashan in the diagnosis and treatment of constipated anorectal diseases based on the traditional Chinese medicine(TCM)inheritance auxiliary platform.Methods:Professor Li Huashan's outpatient cases of anorectal disease with symptoms of constipation were screened,and the constipation outpatient medical record database was established through the TCM inheritance assistance platform V2.5,and the patient's age,Western medicine diagnosis,TCM syndrome type,TCM flavor meridian,core drugs and high-frequency compatibility combinations were summarized.Results:The medical records of 217 patients were selected.The age distribution was normal,and the most common patients were 41~60 years old.The anorectal diseases treated were mostly mixed hemorrhoids,and colorectal tumors,intestinal polyps,and etc.had higher frequency.The TCM syndrome types mainly include dampness and heat downflow syndrome,Qi stagnation and blood stasis syndrome,and liver stagnation and spleen deficiency syndrome.47 medicines were used,and 17 medicines were used with frequency≥80.The top 5 drugs in terms of medication frequency were Baizhu(Atractylodis Macrocephalae Rhizoma),Huangqi(Astragali Radix),Shengdihuang(Rehmanniae Radix Exsiccata seu Recens),Maidong(Ophiopogonis Radix),and Xuanshen(Scrophulariae Radix).There were 17 pairs of association rules at the condition of the support level was 140 and the confidence level was>90%.Commonly used drug combinations included Maidong(Ophiopogonis Radix)-Shengdihuang(Rehmanniae Radix Exsiccata seu Recens),Huangqi(Astragali Radix)-Baizhu(Atractylodis Macrocephalae Rhizoma),Zhiqiao(Aurantii Fructus)-Baizhu(Atractylodis Macrocephalae Rhizoma),and etc.The four Qi attributes were mainly warm and cold,the five taste attributes were sweet and bitter.There were 9 core drugs were summarized,including Huangqi(Astragali Radix),Baizhu(Atractylodis Macrocephalae Rhizoma),Zhiqiao(Aurantii Fructus)and etc.High frequency drugs mainly included tonifying drugs,heat-clearing

关 键 词：肛肠病 便秘 兼症 用药规律 李华山 中医传承辅助平台 数据挖掘 

分 类 号：R256.35[医药卫生—中医内科学]