外周血CC家族趋化因子配体21、CXC趋化因子受体7与阵发性房颤射频消融术后早期复发的相关性分析  

Correlation analysis of peripheral blood CCL21,CXCR7 and early recurrence after radiofrequency ablation of paroxysmal atrial fibrillation

作　　者：朱小山 周汉云[1] 杨峰[1] 张红申[1] 马可忠[1] ZHU Xiaoshan;ZHOU Hanyun;YANG Feng;ZHANG Hongshen;MA Kezhong(Department of Cardiovascular Medicine,Xiangyang Central Hospital,Affiliated Hospital of Hubei University of Arts and Sciences,Xiangyang,Hubei 441021,China)

机构地区：[1]湖北文理学院附属医院、襄阳市中心医院心血管内科,湖北襄阳441021

出　　处：《安徽医药》2023年第11期2233-2236,共4页Anhui Medical and Pharmaceutical Journal

摘　　要：目的探究血清CC家族趋化因子配体21(CCL21)、CXC趋化因子受体7(CXCR7)水平与阵发性房颤射频消融术后早期复发的相关性。方法选取2018年6月至2021年1月襄阳市中心医院收治的122例接受射频消融术治疗的房颤病人为研究对象,根据射频消融术后3个月病人是否出现复发分为早期复发组(19例)和未早期复发组(103例)。采用酶联免疫吸附(ELISA)法检测病人血清中CCL21、CXCR7水平,采用受试者操作特征(ROC)曲线评价血清CCL21、CXCR7预测阵发性房颤射频消融术后早期复发的价值,logistic回归分析影响阵发性房颤射频消融术后早期复发的危险因素。结果与未早期复发组相比,早期复发组病人左心房直径(LAD)、血清超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)及CCL21水平较高(P<0.05),左心室射血分数(LVEF)及血清CXCR7水平较低(P<0.05);ROC结果显示,血清CCL21、CXCR7水平预测术后早期复发的AUC分别为0.88、0.87,CCL21为138.36 ng/L时,CXCR7为2113.83μg/L,具有最优的预测能力,二者联合预测术后早期复发的AUC为0.94,灵敏度为84.20%,特异度为95.10%。logistic回归分析,结果显示高LAD值、CCL21≥138.36 ng/L、CXCR7≤2113.83μg/L是阵发性房颤射频消融术后早期复发的危险因素(P<0.05),高LVEF值是阵发性房颤射频消融术后早期复发的保护因素(P<0.05)。结论术后早期复发的阵发性房颤病人血清中CCL21水平上升,CXCR7水平下降,对阵发性房颤射频消融术后早期复发具有一定的预测价值。Objective To explore the correlation between serum C-C chemokine ligand 21(CCL21)and CXC chemokine receptor type 7(CXCR7)levels and early recurrence after radiofrequency ablation of paroxysmal atrial fibrillation.Methods A total of 122 patients with atrial fibrillation treated by radiofrequency ablation in Xiangyang Central Hospital from June 2018 to January 2021 were selected as the research objects.According to whether the patients had recurrence 3 months after radiofrequency ablation,they were divided into the early recurrence group(19 cases)and the non-early recurrence group(103 cases).Enzyme-linked immunosorbent assay(ELISA)was used to detect the levels of CCL21 and CXCR7 in serum of patients,the receiver operating characteristic(ROC)curve was used to evaluate the value of serum CCL21 and CXCR7 in predicting the early recurrence of paroxysmal atrial fibrillation after radiofrequency ablation,logistic regression was used to analyze the risk factors affecting the early recurrence of paroxysmal atrial fibrillation after radiofrequency ablation.Results Compared with the non-early recurrence group,the early recurrence group had a higher left atrial diameter(LAD),serum hypersensitive C-reactive protein(hs-CRP),tumor necrosis factorα(TNF-α)and CCL21 level(P<0.05),left ventricular ejection fraction(LVEF)and a lower serum CXCR7 level(P<0.05);ROC results showed that the AUC of serum CCL21 and CXCR7 levels for predicting early postoperative recurrence was 0.88 and 0.87,when CCL21 was 138.36 ng/L,CXCR7 was 2113.83μg/L,with the best predictive ability,the AUC of the two combination for predicting early postoperative recurrence was 0.94,the sensitivity was 84.20%,and the specificity was 95.10%.Logistic regression analysis showed that high LAD value,CCL21≥138.36 ng/L,CXCR7≤2113.83μg/L were risk factors for early recurrence after radiofrequency ablation of paroxysmal atrial fibrillation(P<0.05),while high LVEF value was a protective factor for early recurrence after radiofrequency ablation of paroxysmal atrial fibri

关 键 词：心房颤动 射频消融术 CC家族趋化因子配体21 CXC趋化因子受体7 早期复发 

分 类 号：R541.75[医药卫生—心血管疾病]