四项血清标志物联合检测在婴幼儿感染发热早期的临床诊断价值  

Clinical Diagnostic Value of Combination of Four Serum Markers in the Early Stages of Fever in Infants and Young Children with Infections

作　　者：陈芳斌 邹国吉 施钰娟 Chen Fangbin;Zou Guoji;Shi Yujuan(Department of Pediatric,Quangang District Hospital,Quanzhou,Fujian,362000,China)

机构地区：[1]泉州市泉港区医院儿科,福建泉州362000

出　　处：《黑龙江医学》2023年第20期2484-2486,共3页Heilongjiang Medical Journal

摘　　要：目的:观察血常规、C反应蛋白(CRP)、降钙素原(PCT)、白细胞介素-6(IL-6)水平在婴幼儿感染性发热早期诊断中的临床价值。方法:回顾性选取2020年6月—2021年5月泉州市泉港区医院收治的103例1岁以下患儿,通过入院症状分为感染性发热组和正常组,对比入院第1 d患儿的血常规、C反应蛋白(CRP)、降钙素原(PCT)、白细胞介素-6(IL-6)水平变化。结果:感染性发热组与正常组比较在入院第1 d血常规中性粒细胞百分比(N%)、PCT、CRP、IL-6数值,差异有统计学意义(χ^(2)=26.820、5.130、17.920,P<0.05),N%对发热的影响面积大于0.6,差异有统计学意义(P<0.05),灵敏度为60%,特异度77.4%,约登指数37.4%,CRP和IL-6得到的发热的Logic(P)概率对发热的ROC结果,AUC=0.8>0.6,差异有统计学意义(P<0.05),对发热的灵敏度为60%,特异度88.7%,约登指数48.7%。结论:对于感染性发热患儿,入院第1 d天血常规N%、PCT、CRP、IL-6升高明显,可于疾病早期判断婴儿感染情况。Objective:To observe the clinical value of blood routine,C-reactive protein(CRP),procalcitonin(PCT),and inter⁃leukin-6(IL-6)levels in the early diagnosis of infectious fever in infants and children.Methods:103 cases of infants less than 1 year old admitted to the hospital from June 2020 to May 2021 were selected and divided into infectious fever group and normal group.Changes in blood routine,C-reactive protein(CRP),procalcitonin(PCT),and interleukin-6(IL-6)levels on the 1st d of ad⁃mission were compared.Results:On the first day of admission,there was a statistically significant difference between the infec⁃tious fever group and the normal group when comparing the values of routine blood N%,PCT,CRP,and IL-6(χ^(2)=26.820,5.130,17.920,P<0.05).The area of effect of N%on fever was greater than 0.6,and the difference was statistically significant(P<0.05).The sensitivity was 60%,the specificity 77.4%,and the Yoden index 37.4%.The ROC results of Logic(P)probability of fever against fever obtained by CRP and IL-6 showed AUC=0.8>0.6 and the difference was statistically significant(P<0.05).The sensitivity for fever was 60%,specificity 88.7%,and Yoden index 48.7%.Conclusion:In infectious febrile infants,elevated blood N%,PCT,CRP,and IL-6 are evident on the first day of admission,which can be used to determine the infant’s infection in the early stages of the disease.

关 键 词：白介素-6 降钙素原 C反应蛋白 血常规 婴儿发热 临床价值 

分 类 号：R446.11[医药卫生—诊断学]