心房颤动患者血清IL-10、sCD14、FGF-21检测对左心房血栓形成的预测价值  

Predictive value of serum IL-10,sCD14,and FGF-21 for left atrial thrombosis in patients with atrial fibrillation

作　　者：高苏莉 李耀 张兵 韩素霞 GAO Su-li;LI Yao;ZHANG Bing;HAN Su-xia(Department of Cardiovascular Medicine,Shanghai Pudong New Area People's Hospital,Shanghai 201200,CHINA;Department of Cardiovascular Medicine,Shanghai Fengxian District Fengcheng Hospital,Shanghai 201411,CHINA)

机构地区：[1]上海市浦东新区人民医院心血管内科,上海201200 [2]上海市奉贤区奉城医院心血管内科,上海201411

出　　处：《海南医学》2023年第19期2835-2840,共6页Hainan Medical Journal

摘　　要：目的观察心房颤动患者血清白细胞介素-10(IL-10)、可溶性白细胞分化抗原14(sCD14)、成纤维细胞生长因子-21(FGF-21)水平,并探究其对左心房血栓形成的预测价值。方法选取2020年8月至2021年8月上海市浦东新区人民医院收治的86例心房颤动患者作为观察组,另选取60例健康体检者作为对照组。比较两组受检者的血清IL-10、sCD14、FGF-21水平,以及观察组中发生与未发生左心房血栓患者的临床资料、超声心动图指标和血清IL-10、sCD14、FGF-21水平,采用Logistic回归分析心房颤动患者左心房血栓形成影响因素,采用Pearson相关系数模型分析血清IL-10、sCD14、FGF-21水平与超声心动图指标的相关性,采用受试者工作特征曲线(ROC)评价血清IL-10、sCD14、FGF-21水平对心房颤动患者左心房血栓形成的预测价值。结果观察组患者的血清IL-10水平为(18.74±5.32)pg/mL,明显低于对照组的(25.87±7.49)pg/mL,sCD14、FGF-21水平分别为(12.58±4.17)mg/L、(224.15±28.76)pg/mL,明显高于对照组的(4.82±1.23)mg/L、(145.16±13.94)pg/mL,差异均有统计学意义(P<0.05);发生左心房血栓患者的左心房内径(LAD)、sCD14、FGF-21水平分别为(44.56±6.13)mm、(16.94±4.06)mg/L、(250.87±32.77)pg/mL,明显高于未发生患者的(39.12±4.98)mm、(11.66±2.98)mg/L、(218.50±25.69)pg/mL,IL-10水平为(15.26±4.12)pg/mL,明显低于未发生患者的(19.48±5.94)pg/mL,差异均有统计学意义(P<0.05);经Logistic回归分析结果显示,LAD及血清IL-10、sCD14、FGF-21均为心房颤动患者左心房血栓形成的影响因素(P<0.05);经Pearson相关系数模型分析结果显示,心房颤动患者血清IL-10与超声心动图指标LAD呈负相关(r=-0.809,P<0.05),sCD14、FGF-21水平与超声心动图指标LAD呈正相关(r=0.772、0.832,P<0.05);血清IL-10、sCD14、FGF-21联合预测心房颤动患者左心房血栓形成的曲线下面积(AUC)值大于单独指标(P<0.05)。结论心房颤动患者血清IL-10、sCD14、FObjective To detect the levels of serum interleukin 10(IL-10),soluble leukocyte differentiation antigen 14(sCD14),and fibroblast growth factor 21(FGF-21)in patients with atrial fibrillation,and explore their predictive value for left atrial thrombosis.Methods Eighty-six patients with atrial fibrillation admitted to Shanghai Pudong New Area People's Hospital from August 2020 to August 2021 were selected as the observation group,and 60 healthy people undergoing physical examination were selected as the control group.The serum IL-10,sCD14,and FGF-21 levels were compared between the two groups.The clinical data,echocardiographic indicators,and serum IL-10,sCD14,and FGF-21 levels were compared between the patients with or without left atrial thrombosis in the observation group.Logistic regression analysis was used to analyze the influencing factors of left atrial thrombosis in patients with atrial fibrillation.Pearson correlation coefficient model was used to analyze the correlation between serum IL-10,sCD14,FGF-21 levels and echocardiographic indicators,and receiver operating characteristic curve(ROC)was used to evaluate the predictive value of serum IL-10,sCD14,FGF-21 levels for left atrial thrombosis in patients with atrial fibrillation.Results The serum IL-10 level of the observation group was(18.74±5.32)pg/mL,significantly lower than(25.87±7.49)pg/mL of the control group;sCD14 and FGF-21 levels were(12.58±4.17)mg/L and(224.15±28.76)pg/mL,respectively,significantly higher than(4.82±1.23)mg/L and(145.16±13.94)pg/mL of the control group;the differences were statistically significant(P<0.05).The levels of left atrial inner diameter(LAD),sCD14,and FGF-21 in patients with left atrial thrombosis were(44.56±6.13)mm,(16.94±4.06)mg/L,and(250.87±32.77)pg/mL,respectively,which were significantly higher than(39.12±4.98)mm,(11.66±2.98)mg/L,and(218.50±25.69)pg/mL in patients without left atrial thrombosis;level of IL-10 was(15.26±4.12)pg/mL,which was significantly lower than(19.48±5.94)pg/mL in pa-tients without l

关 键 词：心房颤动 左心房血栓形成 白细胞介素-10 可溶性白细胞分化抗原14 成纤维细胞生长因子-21 预测价值 

分 类 号：R541.75[医药卫生—心血管疾病]