富马酸替诺福韦二吡呋酯对骨代谢影响的研究进展  

Research progress on effect of tenofovir disoproxil fumarate on bone metabolism

作　　者：池伟进 杨均政 陈柏豪 陈楚仪 何琪 陈鹏[1] Chi Weijin;Yang Junzheng;Chen Baihao;Chen Chuyi;He Qi;Chen Peng(Orthopedics and Traumatology Center,First Affiliated Hospital of Chinese Medicine University of Guangzhou,Guangzhou 510405,China)

机构地区：[1]广州中医药大学第一附属医院骨伤中心,广州510405

出　　处：《药物不良反应杂志》2023年第9期564-569,共6页Adverse Drug Reactions Journal

摘　　要：富马酸替诺福韦二吡呋酯(TDF)是临床常用的抗人类免疫缺陷病毒和乙型肝炎病毒药物,其骨毒性一直是临床关注的重点问题。TDF的骨毒性与其肾小管毒性继发的低磷血症有关。目前,对TDF导致的骨代谢改变尚没有较系统的描述。本文从TDF对成骨细胞和破骨细胞的影响、对骨转换的影响和对骨结构和骨折的影响3个方面,对TDF对骨代谢的影响进行了综述。Tenofovir dipivoxil fumarate(TDF)is a anti human immunodeficiency virus and hepatitis B virus drug,which is commonly used in clinic.The osteotoxicity of TDF has always been a key issue of clinical concern.The bone toxicity of TDF is related to hypophosphatemia secondary to renal tubular toxicity.At present,there are few systematic descriptions of bone metabolism changes caused by TDF.In this paper,the effects of TDF on bone metabolism are reviewed from 3 aspects:its effects on osteoblasts and osteoclasts,bone turnover,and bone structure and fracture.

关 键 词：替诺福韦 骨细胞 骨脱矿物质 病理性 骨重建 骨质疏松症 骨折 药物相关副作用和不良反应 

分 类 号：R969[医药卫生—药理学]