醒脑健神方治疗脑梗死急性期痰热腑实证  

Clinical observation on the treatment of syndrome of excessive fu-viscera caused by phlegm-heat in acute stage of cerebral infarction with Xingnao Jianshen prescription

作　　者：王新娜 马春玉 徐巧丽 苏晶 赵德喜[1] WANG Xinna;MA Chunyu;XU Qiaoli;SU Jing;ZHAO Dexi(Brain Disease Research Center,the Affiliated Hospital of Changchun University of Chinese Medicine,Changchun 130021,China;College of Chinese Medicine,Changchun University of Chinese Medicine,Changchun 130117,China)

机构地区：[1]长春中医药大学附属医院脑病中心,长春130021 [2]长春中医药大学中医学院,长春130117

出　　处：《长春中医药大学学报》2023年第10期1115-1119,共5页Journal of Changchun University of Chinese Medicine

基　　金：吉林省中医药科技项目(2022036);长春市科技局发展计划项目(21ZGM32)。

摘　　要：目的探讨醒脑健神方对缺血性中风痰热腑实证患者的临床疗效。方法选取2019年1月-2021年1月,于长春中医药大学附属医院脑病中心、吉林大学中日联谊医院神经内科确诊的痰热腑实证急性脑梗死患者72例,长春中医药大学附属医院入组患者为观察组、吉林大学中日联谊医院入组患者为对照组,每组36例。对照组采用指南中推荐的西医基础治疗,观察组在对照组基础上给予醒脑健神方治疗。比较2组临床疗效、治疗前后NIHSS评分、BI评分、mRS评分、中医证候要素量表积分、患者的首次通便时间。结果观察组治疗总有效率(86.67%,26/30)高于对照组(81.82%,27/33)。治疗(10±1)d后,2组NIHSS评分无统计学差异(P>0.05),观察组BI及mRS评分较对照组有改善(P<0.05);2组治疗后痰湿、内火、血瘀证候表现疗效显著(P<0.05),2组内风证候方面未见统计学差异(P>0.05);2组便秘情况在第3天、第7天组间比较差异明显(P<0.05),其他时间点2组症状改善情况对比无统计学差异(P>0.05)。治疗期间,患者临床治疗期间及后期随访过程中均未出现恶心、呕吐、皮疹等不良事件。结论应用醒脑健神方与西医基础治疗的联合干预方法,可以更好地改善患者神经功能缺损、日常生活能力及残障功能恢复情况,更好地改善患者的痰湿、内火、血瘀中医证候表现情况,提高患者生活质量,值得临床推广应用。Objective To explore the clinical efficacy of Xingnao Jianshen prescription in the treatment of the patients with apoplexy syndrome of excessive fu-viscera caused by phlegm-heat.Methods From January 2019 to January 2021,72 patients with acute cerebral infarction due to syndrome of excessive fu-viscera caused by phlegm-heat diagnosed in the Brain Disease Research Center of the Affiliated Hospital of Changchun University of Chinese Medicine and the Department of Neurology of China Japan Union Hospital of Jilin University were selected.The patients enrolled in the Affiliated Hospital of Changchun University of Chinese Medicine were the observation group,and the patients enrolled in China Japan Union Hospital of Jilin University were the control group,with 36 cases in each group.The control group was treated with basic western medicine recommended in the guidelines for cerebral infarction of western medicine,while the observation group was treated with Xingnao Jianshen prescription on the basis of the the treatment of the control group.The clinical efficacy,and NIHSS score,BI score,mRS score and traditional Chinese medicine(TCM)syndrome element scale score before and after treatment,and thefirst time of defecation of patients in the two groups were compared.Results The total effective rate of treatment in the observation group(86.67%,26/30)was higher than that in the control group(81.82%,27/33).After the treatment for(10±1)days,there was no statistically significant difference in NIHSS scores between the two groups(P>0.05),and compared with the control group,BI score and mRS score in the observation group were improved(P<0.05);After treatment,the curative effect of phlegm dampness,endognousfire and blood stasis syndrome was significant in the two groups(P<0.05),but there was no statistically significant difference in endogenous wind syndrome between the two groups(P>0.05);There was statistically significant difference in constipation between the groups on the 3rd and 7th day(P<0.05),and there was no statisticall

关 键 词：醒脑健神方 脑梗死 痰热腑实证 临床观察 

分 类 号：R255[医药卫生—中医内科学] R741[医药卫生—中医学]