Carrier-free nanodrugs for stemness inhibition-enhanced photodynamic therapy  

作　　者：Yuwei Liu Kaiqi Long Tianyi Wang Weirong Kang Weiping Wang 

机构地区：[1]State Key Laboratory of Pharmaceutical Biotechnology,The University of Hong Kong,Hong Kong,China [2]Department of Pharmacology and Pharmacy,Li Ka Shing Faculty of Medicine,The University of Hong Kong,Hong Kong,China [3]Laboratory of Molecular Engineering and Nanomedicine,Dr.Li Dak-Sum Research Centre,The University of Hong Kong,Hong Kong,China

出　　处：《Aggregate》2023年第3期84-93,共10页聚集体（英文）

基　　金：Research Grants Council of Hong Kong,Grant/Award Number:27115220;Ming Wai Lau Centre for Reparative Medicine Associate Member Program。

摘　　要：Cancer stem cell(CSC)has been considered a key driver of tumor growth,recurrence,and metastasis due to its self-renewal and tumor initiation capacities called stemness.Stemness is also responsible for the high resistance of CSC to current therapeutic strategies,including photodynamic therapy(PDT)and chemotherapy.In this study,a carrier-free nanodrug(designated as MKCe6 nanoparticle[NP])selfassembled by photosensitizer chlorin e6(Ce6)and stemness inhibitor MK-0752 was prepared for effective tumor repression.Stemness inhibition caused by MK-0752 could sensitize CSCs to PDT.Benefiting from the high drug-loading capacity and efficient cellular internalization,MKCe6 NPs exhibited good performance in PDT and stemness inhibition.In this way,effective tumor growth repression and tumorigenesis inhibition by MKCe6 NPs were observed both in vitro and in vivo.This self-delivery nanodrug for stemness inhibition-enhanced photodynamic therapy may provide new insights for clinical cancer therapy.

关 键 词：cancer stemness NANOMEDICINE Notch pathway photodynamic therapy SELF-ASSEMBLY 

分 类 号：TB383.1[一般工业技术—材料科学与工程]