赤芍抗脑缺血再灌注损伤的作用研究进展  

Research on Progress in the Treatment of Paeoniae Rubra Radix Against Cerebral Ischemia-Reperfusion Injury

作　　者：刘玉峰[1] 白静 刘畅[1] 许肇初 LIU Yu-feng;BAI Jing;LIU Chang;XU Zhao-chu(School of Pharmaceutical Sciences,Liaoning University,Shenyang 110036,China)

机构地区：[1]辽宁大学药学院,辽宁沈阳110036

出　　处：《辽宁大学学报（自然科学版）》2023年第3期193-199,F0002,共8页Journal of Liaoning University：Natural Sciences Edition

基　　金：国家自然科学基金项目(81403177);辽宁省自然科学基金项目(2021-MS-150);辽宁省高等学校创新人才支持计划项目(LR2018047)。

摘　　要：脑缺血再灌注损伤是缺血和缺氧导致的脑部损伤,具有较高的发病率和死亡率.赤芍中的活性成分如单萜苷类成分可通过参与调控酪氨酸、柠檬酸循环、苯丙氨酸等重要代谢途径以及有效降低炎症因子的表达,减轻自由基损伤等机制发挥治疗作用,而脑缺血再灌注损伤的发生与细胞正常功能受损、代谢通路的异常变化(如柠檬酸循环等)有关,因此推测赤芍可能对脑缺血再灌注损伤有一定的治疗效果.为进一步了解赤芍治疗缺血性脑血管病的效果与治疗机制,本文对缺血性脑血管疾病的发病原因与赤芍的抗脑缺血再灌注损伤的治疗机制进行归纳总结,为赤芍的临床用药及脑缺血再灌注损伤的治疗提供依据.Cerebral ischemia-reperfusion injury is a brain injury caused by ischemia and hypoxia with high morbidity and mortality.Paeoniflorin and other monoterpene glycosides in paeoniae rubra radix can participate in regulating tyrosine,citric acid cycle,phenylalanine and other important metabolic pathways and effectively reduce the expression of inflammatory factors.The mechanism of inhibiting the expression of inflammatory factors and alleviating free radical injury and some metabolic pathways(such as citric acid circulation,etc.)play a therapeutic role,and it might be related to the occurrence of cerebral ischemia-reperfusion injury.To provide guideline for the treating ischemic cerebrovascular disease,this paper summarizes the therapeutic effect and mechanism of paeoniae rubra radix and the pathogenesis and treatment mechanism of ischemic cerebrovascular disease.

关 键 词：赤芍 脑缺血再灌注损伤 药效物质基础 治疗机制 

分 类 号：R285.5[医药卫生—中药学]