青黛治疗带状疱疹的网络药理学机制探讨  

Network Pharmacological Mechanism of Indigo Naturalis in the Treatment of Herpes Zoster

作　　者：黄靖 杨磊 林艺真 颜焱煌 李伟[3] 包君丽 HUANG Jing;YANG Lei;LIN Yi-zhen;YAN Yan-huang;LI Wei;BAO Jun-li(Fujian Provincial Key Laboratory of Ecology-Toxicological Effects&Control for Emerging Contaminants,College of Environmental and Biological Engineering,Putian University,Putian 351100,China;Key Laboratory of Ecological Environment and Information Atlas Fujian Provincial University,Putian 351100,China;Medical School,Qinghai University,Xining 810016,China)

机构地区：[1]莆田学院环境与生物工程学院,福建省新型污染物生态毒理效应与控制重点实验室,福建莆田351100 [2]生态环境及其信息图谱福建省高等学校重点实验室,福建莆田351100 [3]青海大学医学院,青海西宁810016

出　　处：《辽宁大学学报（自然科学版）》2023年第3期208-216,共9页Journal of Liaoning University：Natural Sciences Edition

基　　金：福建省自然科学基金(2022J01132911,2022J01132905);福建省科技创新联合资金项目(2018C0010);福建省教育厅中青年教师项目(JAT220303);莆田市区域重点项目(2020GJQ005);莆田市科技局项目(2020NP001)。

摘　　要：青黛是治疗疱疹、腮腺炎以及银屑病等的主要中药材之一.本文基于网络药理学方法,分析青黛治疗带状疱疹机理和分子靶点.通过多个数据库的数据挖掘筛选青黛主要化合物及其靶点并获得带状疱疹相关交集靶标基因,利用Cytoscape 3.7.2软件构建靶蛋白互作网络图和青黛-带状疱疹-靶点-通路网络图,并对青黛治疗带状疱疹潜在作用靶标进行GO分类和KEGG(Kyoto encyclopedia of genes and genomes)通路富集分析.数据挖掘结果表明:青黛治疗带状疱疹有27个候选活性成分、233个潜在作用靶标及176条通路,为后续研究青黛治疗带状疱疹的作用机制提供了新的研究方法.Indigo naturalis was the main Chinese medicine in the treatment of herpes zoster,mumps and psoriasis,etc.In this study,we analyzed the mechanism and molecular targets of indigo naturalis in the treatment of herpes zoster based on network pharmacology.The main compounds and targets of indigo naturalis were screened through data mining of multiple databases,and the herpes zoster related intersection target genes were obtained.The target protein interaction network diagram and indigo naturalis herpes zoster target pathway network diagram were constructed by using Cytoscape 3.7.2 software.GO classification and KEGG(Kyoto encyclopedia of genes and genornes)pathway enrichment were performed on potential targets of indigo naturalis for herpes zoster treatment.As a result,there were 27 candidate active ingredients,233 potential targets and 176 pathways in the treatment of herpes zoster.Mining the therapeutic targets and signal pathways of indigo naturalis in the treatment of herpes zoster based on network pharmacology provides a new research method for studying the mechanism of indigo naturalis in the treatment of herpes zoster.

关 键 词：青黛 带状疱疹 网络药理学 机制 

分 类 号：R285[医药卫生—中药学]